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Neonatology Infant Pulmonary Disorders

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Neonatology Infant Pulmonary Disorders

Center for Infant Pulmonary Disorders

The Center for Infant Pulmonary Disorders is to be a world leader in understanding the causes of, and improving the treatment of pulmonary disorders developing in preterm and term infants. We will combine relevant basic, translational, and clinical research with epidemiological studies. We will support long term follow up assessment of lung disease. The beneficiaries of the research include children in our city, region, and nation, who suffer from these life threatening disorders. 

In 2008 the Center for Infant Pulmonary Disorders (CIPD) was created at Children's Mercy-Kansas City. The vision of this Center is to harness and channel the outpouring of new knowledge in the world of biosciences into reducing human pain and suffering in both preterm and full-term infants born with or developing pulmonary disorders. The CIPD is an integrated, transdisciplinary research entity. With its focus on translational research, early phase and pivotal clinical trials, post clinical trial surveillance, and quality improvement initiatives, the CIPD seeks to utilize many approaches to ameliorate this tremendous medical and public health problem.

About Chronic Pulmonary Disorders

Chronic pulmonary disorders arising at birth or in the first days of postnatal life remain among the most important challenges in pediatric medicine. For example, bronchopulmonary dysplasia (BPD) is the most common and important pediatric pulmonary disorders in the United States. Severe BPD develops in 10,000-13.000 infants annually and imposes childhood long and possibly lifelong impairment to lung health. This yearly incidence is at least 5 times greater than that of cystic fibrosis, almost two times the incidence of congenital heart disease requiring treatment in the neonatal period, and nearly the yearly incidence of all new pediatric cancers combined. Safe and efficacious therapies for BPD do not exist. In addition to BPD arising in very preterm infants, other chronic pulmonary disorders plague certain groups of full term infants, adding to the overall public health burden.

Research Grants and Initiatives

The center continually pursues new studies which combine in-depth research and potentially effective clinical treatments to minimize the short-term and lifelong effects of pulmonary disorders. Our team also provides long-term follow-up assessments to help maintain long-term health.

The Center for Infant Pulmonary Disorders is involved with many research initiatives and supported through grants and endowments. These ongoing research efforts are leading to new treatment breakthroughs for infants with chronic pulmonary disorders.

Current External Research Grants

  • >NIH/NHLBI U-O1HL94338 TOLSURF (Late Surfactant) RCT Multicenter Clinical Trial Network to Test the Role of "Late" Surfactant in Infants (2009-2014)
    Overall principal investigator: R.A. Ballard, MD (UCSF-SOM)
    Local principal investigator and steering committee member: W.E. Truog, MD
  • NICHD NRN U-10 HD068284 Children's Mercy-Truman-UMKC Center: A New Addition for the Next Five Years (2011-2016)
    This cooperative grant builds on existing areas of excellence at Children's Mercy Kansas City including the Fetal Health Center, the Neonatal Extracorporeal Membrane Oxygenation program, the Center for Infant Pulmonary Disorders, the infant home ventilator program, the ongoing federal and other externally funded clinical research, and our demonstrated excellent clinical outcomes.
    Principal investigator: W.E. Truog, MD

Special Endowments

  • Cooper Connor Endowed Fund for Pulmonary Research
  • Sosland Family Endowed Chair in Neonatal Research

Peer-Reviewed Publications

  • Nyp MF, Taylor JB, Norberg M, Truog WE.  Impaired growth at birth and bronchopulmonary dysplasia classification: beyond small for gestational age. Am J Perinatol. (2014)
  • Taylor JB, Nyp MF, Norberg M, Dai H, Escobar H, Ellerbeck E, Truog WE. Impact of intercurrent respiratory infections on lung health in infants born <29 weeks with bronchopulmonary dysplasia. J Perinatol. 34(3):223-228 (2014)
  • Truog WE, Nyp MF, Taylor J, Gratny LL, Escobar H, Manimtim WM, Lachica CI, Khmour A, Oluola OO, Oshodi AA, Norberg M, Dai H, Pallotto EK. Infants born at <29 weeks: pulmonary outcomes from a hybrid perinatal system. J Perinatol. 34(1):59-63 (2014)
  • Keller R, Merrill JD, Black DM, Steinhorn RH, Eichenwald EC, Durand DJ, Ryan RM, Truog WE, Courtney SE, Ballard PL, Ballard RA. Late administration of surfactant replacement therapy increasessurfactant protein-B content: a randomized pilot study. Pediatr Res. 72(6):613-619 (2012)
  • Nyp M, Sandritter T, Poppinga N, Simon C, Truog WE. Sildenafil citrate, bronchopulmonary dysplasia and disordered pulmonary gas exchange:any benefits? J Perinatol. 32(1):64-69 (2012)
  • Merrill JD, Ballard PL, Courtney SE, Durand, DJ, Hamvas A, Hibbs AM, Lu KW, Ryan RM, Reynolds AM, Spence K, Steinhorn RH, Truog WE, Eichenwald EC, Ballard RA.  Pilot trial of latebooster doses of surfactant for ventilated premature infants. J Perinatol. 31:599-606 (2011)
  • Petrikin JE, Gaedigk R, Leeder JS, Truog WE. Selective toll-like receptor expression in human fetal lung. Pediatr Res 68(4):335-338 (2010)
  • Truog WE. 21stCentury Use for Surfactant? (editorial) Pediatrics. 123:173 (2009)

Other Activities

  • Maintenance of a chronic lung disease team in the Children's Mercy Neonatal Intensive Care Unit (NICU) that supports increased and earlier referrals of patients with complex lung and airway problems
  • Support of the Children's Mercy Home Infant Ventilator Program
  • Creation of comprehensive data repository for clinical trial projects
  • Follow-up study of pulmonary function/exercise testing of a cohort of 6-10 year old children from prior research protocol
  • Researching new uses of surfactant for treating infant pulmonary disorders

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