Center for Infant Pulmonary Disorders
The Center for Infant Pulmonary Disorders (CIPD) exists to reduce pain and improve the quality of life for preterm and full-term infants who are born with or develop pulmonary disorders. We focus on translational early phase and pivotal clinical trials, as well as post clinical trial surveillance, in our multifaceted approach to addressing this medical and public health problem.
Our program specializes in early stage clinical research for a critically ill and understudied population of infants and toddlers. It combines the expertise of physicians trained in developmental pharmacology with that of specialists in pulmonary and long term developmental follow up.
Support for this Center sustains its dedicated database and biorepository infrastructure, which enables local research along with international efforts through the BPD Collaborative to develop safe and effective patient treatments, and to improve quality of life outcomes.
About Chronic Pulmonary Disorders
Chronic pulmonary disorders that arise at birth or in the first days of postnatal life remain among the most important challenges in pediatric medicine. For example, bronchopulmonary dysplasia (BPD) is the most common and significant pediatric pulmonary disorder in the United States. Severe BPD develops in approximately 10,000 to 13,000 infants annually and may impair lung health throughout childhood and sometimes, throughout the person’s life. In addition to BPD in very preterm infants, other chronic pulmonary disorders plague certain preterm and full-term infants, adding to the overall public health burden.
Financial support for the CIPD
Endowments
Cooper Connor Endowed Fund for Pulmonary Research
Sosland Family Endowed Chair in Neonatal Research
Others sources of support
Courtney S. Turner Charitable Trust
Children’s Mercy Kansas City
Unique research
The CIPD operates two IRB-approved repositories at Children’s Mercy. Investigators affiliated with Children’s Mercy and their collaborators may utilize these research assets to study infant pulmonary disorders.
Infant Pulmonary Data Repository
This repository banks clinical data from pulmonary patients admitted to Children’s Mercy during the first year of life and follows their outcomes until adulthood.
Infant Pulmonary Biorepository
This repository prospectively banks blood, urine, tracheal aspirates, and buccal swabs longitudinally from infant pulmonary patients admitted to Children’s Mercy.
Clinical connections
Chronic Lung Disease team
The CIPD helps support the multidisciplinary Chronic Lung Disease team, which serves infants with complex lung and chronic airway problems.
Tracheostomy and Home Ventilator Program
CIPD physicians lead the tracheostomy and home ventilator outpatient clinic, which follows patients discharged from a Children’s Mercy NICU or PICU and continue to receive respiratory support.
Multicenter relationships
The CIPD is a founding member of the BPD Collaborative established to fill knowledge gaps in the treatment of infants with bronchopulmonary dysplasia (BPD). Nearly 20 medical sites from the United States and Europe are focusing their research collaboration on long-term pulmonary support for critically ill infants.
Children’s Hospitals Neonatal Consortium
The CIPD participates in the Children’s Hospitals Neonatal Consortium (CHNC), especially its BPD and Congenital Diaphragmatic Hernia (CDH) Forums. This consortium strives to improve care for high-risk infants by providing a platform to compare quality care and outcomes across Level IV neonatal intensive care units (NICUs).
Affiliated Faculty
William E. Truog, MD Neonatology
Director of the Center for Infant Pulmonary Disorders; Director of Clinical Research for the Division of Neonatology
Professor of Pediatrics, University of Missouri-Kansas City School of Medicine
Michael F. Nyp, DO, MBA Neonatology
Director of the Infant Pulmonary Biorepository and Co-Director of the Infant Pulmonary Data Repository, Assistant Director of the Donald Thibeault Neonatal Research Laboratory, Resident Research Committee Chair, and Associate Professor of Pediatrics, University of Missouri-Kansas City School of Medicine
Winston M. Manimtim, MD Neonatology
Director of the Infant Tracheostomy and Home Ventilator Program
Professor of Pediatrics, University of Missouri-Kansas City School of Medicine
Research highlights from the CIPD
Precision Therapeutics
With support from the CIPD, ongoing steroid response studies use pharmacogenomics, transcriptomics, metabolomics, and phenotype associations to optimize medical treatments with improved clinical outcomes in preterm infants with BPD. In a 2018 edition of Pediatric Research, Tamorah Lewis published, “Genetic variation in CRHR1 is associated with short-term respiratory response to corticosteroids in preterm infants at risk for bronchopulmonary dysplasia”. In a 2018 edition of Pediatric Pulmonology, Alain Cuna published, “Timing of postnatal corticosteroid treatment for bronchopulmonary dysplasia and its effect on outcomes.”
BPD Collaborative
CIPD faculty participate in six working groups dedicated to specialized aspects of BPD diagnosis and/or treatment. Dr. Truog chairs the pharmacology group, while others also study nutrition, ventilator strategies including Neurally Adjusted Ventilatory Assist (NAVA), pulmonary hypertension, epidemiology, and outpatient transition. In an ongoing effort to establish an international research data repository, the CIPD provides local data to facilitate collaborative BPD research and innovation. Publications supported by the BPD Collaborative include: “Point Prevalence Clinical Characteristics and Treatment Variation for Infants with Severe BPD”, Am. J. Perinat 2015, which demonstrated great variability among the then 8 centers in pharmacological treatment of infants with severe BPD. A second publication, “Inter disciplinary Care of Children with severe BPD (J. Pediatr 2017, 81:12-28), provides expert opinion on a variety of issues about BPD and identifies knowledge gaps in treatment options for these infants.
Contact Us
Jim McBrien, CIPD Administrative Coordinator
jdmcbrien@cmh.edu
(816) 234-3592
- Neonatology
- Congenital Heart Disease Screening
- Neonatal Intensive Care Unit
- NICU Patient Family Advisory Council
- Feeding Clinic
- NEON Clinic
- Extracorporeal Membrane Oxygenation Program
- Neonatal Follow-Up Clinics
- Center for Infant Pulmonary Disorders
- Neonatal-Perinatal Medicine Fellowship
- Meet the Team