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Care Process Models (CPMs) promote evidence based, safe, and high-value care for patients with common or high-risk clinical conditions when national or international guidelines are not available or applicable. CPMs are informed by methodical review of scientific literature and the consensus of a multidisciplinary committee of subject matter experts and key stakeholders at Children’s Mercy Kansas City. Processes within CPMs may be specific to Children’s Mercy Kansas City and should be evaluated before applying to a different setting.   

Algorithms associated with this CPM for viewing on a smartphone or computer: 

Algorithms associated with this CPM for viewing as a PDF: 

Inclusion and exclusion criteria


  • Patients requiring anticoagulation therapy or prophylaxis. 


  • Patients on ECMO, cardiac bypass pump, hemodialysis or continuous renal replacement therapy.  
  • Anticoagulation to maintain patency of arterial or central venous catheters. 

Team members involved in the development: 

  • Shannon Carpenter MD, MS | Hematology/Oncology/BMT | Committee chair 
  • Lauren Amos, MD | Hematology/Oncology/BMT | Committee member
  • Michael Rose, PharmD | Pharmacy | Committee member

EBP Committee Members

  • Todd Glenski, MD, MSHA, FASA | Anesthesiology, Evidence Based Practice
  • Jarrod Dusin, MS, RD, CPHQ | Evidence Based Practice

Publication dates: 

  • Finalized date: 2016; 7/27/2018; 10/31/2019; 2/23/2022
  • Next expected revision date: 2/2025

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This care process model does not establish a standard of care to be followed in every case. It is recognized that each case is different, and those individuals involved in providing health care are expected to use their judgment in determining what is in the best interests of the patient based on the circumstances existing at the time. It is impossible to anticipate all possible situations that may exist and to prepare care process models for each. Accordingly, this care process model should guide care with the understanding that departures from them may be required at times.