Rationale, current evidence, and consensus statement:
The 2015 Red Book and the 2015 CDC Treatment Guidelines for STD's recommends that young infants with C. trachomafis conjunctivitis may be treated with oral azithromycin, 20 mg/kg once daily for 3 days OR oral erythromycin, 50 mg/kg/day divided 4 times per day for 14 days. Neonates treated with either oral azithromycin or erythromycin do not need additional treatment with topical erythromycin. Based on current literature the care standardization team recommends, the use of azithromycin for treatment of neonatal conjunctivitis secondary to C. trachomatis.
Committee on Infectious Diseases. (2015). Red Book: Report of the Commitee on Infectious Diseases (2015) (Kimberlin Brady, MT, Jackson & Long, SS Eds. 30 ed.).
Workowski, K. A., Bolan, G. A., Centers for Diseme, C., & Prevention. (2015). Sexually transmitted diseases treatment guidelines, 2015. NLMTVR Recomm Rep, 64(RR-03), 1-137.