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Clinical Pathways promote evidence based, safe, and high-value care for patients by providing clinical recommendations and standard processes.  They are developed by multidisciplinary committees of subject matter experts, informed by methodical review of available evidence and consensus among committee members.

The UTI/Pyelonephritis (Pyelo) Synopsis provides a high level overview of the care standards employed for this Clinical Pathway. 

Algorithms associated with this Clinical Pathway: 

Inclusion and exclusion criteria 


  • Infants > 60 days of age. 
  • Healthy child with possible or confirmed first-time or recurrent UTI.


  • Chronic kidney disease.
  • Suspected or known genitourinary abnormalities, such as (but not limited to): previous genitourinary surgery (other than circumcision), neurogenic bladder or bowel conditions, obstructive uropathy, vesicoureteral reflux.
  • Septic shock.
  • Presumed or definite meningitis.
  • Immunocompromised host.
  • Pregnancy.
  • Concern for sexual abuse.

Committee members and representation involved in the development: 

  • Adrienne DePorre MD | Hospital Medicine | Committee Chair  
  • Rana El Feghaly MD, MSCI | Infectious Diseases | Committee Member  
  • Allison Hadley MD | Emergency Medicine | Committee Member  
  • Amanda Nedved MD | Urgent Care | Committee Member
  • Christine Scob, DO | Hospital Medicine | Committee Member  
  • Donna Wyly MSN, RN, APRN, CPNP-AC, PPCNP-BC, ONC | Urgent Care | Committee Member  
  • Joel Koenig MD | Urology | Ad hoc Committee Member 

MIT Committee Members:

  • Amber Lanning | Provider Clinical Informatics  
  • Tracy Taylor | Medical Informatics  
  • George Abraham MD | Medical Informatics  

EBP Committee Members: 

  • Kathleen Berg MD, FAAP | Evidence Based Practice & Hospital Medicine  
  • Jacqueline (Jackie) Bartlett PhD, RN | Evidence Based Practice 

Publication dates:

  • Finalized date: 03/2022
  • Next expected revision date: 03/2025 

Concerns with content: 

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These pathways do not establish a standard of care to be followed in every case. It is recognized that each case is different, and those individuals involved in providing health care are expected to use their judgment in determining what is in the best interests of the patient based on the circumstances existing at the time. It is impossible to anticipate all possible situations that may exist and to prepare a pathway for each. Accordingly, these pathways should guide care with the understanding that departures from them may be required at times.