Goals of Therapy

Goals of therapy should be individualized based on clinical picture including underlying etiology and patient response to interventions

Midazolam

Pentobarbital

Ketamine

Seizure control (note goal is generally NOT burst suppression):

Seizure cessation -or-
Return to seizure baseline -or-
Less than 5 minutes of seizure activity per hour

Burst suppression with bursts occurring once every 15-30 seconds

If bursts are more frequent, refer to pentobarbital titration algorithm
If bursts are less frequent, consider decreasing infusion by 0.5 mg/kg/hr

Seizure control (note goal is generally NOT burst suppression):

Seizure cessation -or-
Return to seizure baseline -or-
Less than 5 minutes of seizure activity per hour