Measles Postexposure Prophylaxis (PEP)
For Individuals who are NOT pregnant or immunocompromised
|
Age Group |
Immune Status |
Time Since Exposure |
Recommended PEP |
Home Quarantine Recommendations |
|
All ages (≥ 6 months) |
Documented immunity |
Any time |
PEP not indicated. Has documented immunity (2 MMR doses, IgG positive, or lab confirmation of disease). |
None |
|
< 6 months |
Nonimmune (because of age) |
0–6 days |
Immune Globulin Intramuscular (IGIM) 0.5ml/kg IM (max dose= 15mL) |
Quarantine for 28 days after last exposure |
|
>6 days |
PEP not indicated (too late) |
Quarantine for 21 days after last exposure |
||
|
6 – 11 months |
Nonimmune |
0 – 3 days (≤ 72 hours) |
MMR vaccine (preferred) |
No quarantine if MMR given |
|
4 – 6 days
|
Immune Globulin Intramuscular (IGIM) 0.5ml/kg IM (max dose= 15 mL) |
Quarantine for 28 days after last exposure |
||
|
> 6 days |
PEP not indicated (too late) |
Quarantine for 21 days after last exposure |
||
|
≥ 12 months |
Nonimmune (0 MMR doses or IgG negative) |
0 – 3 days (≤ 72 hours) |
MMR vaccine |
No quarantine if MMR given |
|
> 3 days |
PEP not typically indicated* |
Quarantine for 21 days, then give MMR for future immunity |
||
|
1 dose of MMR |
Any time |
Give 2nd MMR vaccine dose if ≥ 28 days from 1st dose |
No quarantine needed (person had 1 dose when exposed) |
For individuals who ARE pregnant or immunocompromised
|
Health Status |
Age Group |
Immune Status |
Time Since Exposure |
Recommended PEP |
Home Quarantine Recommendations |
|
Severely Immunocompromised |
All Ages |
Will need IG regardless of immune status |
0–6 days |
Immune Globulin Intravenous (IGIV) 400 mg/kg IV (intravenously) |
Quarantine for 28 days after last exposure |
|
>6 days |
PEP not indicated (too late) |
Quarantine for 21 days after last exposure |
|||
|
Pregnant |
N/A |
Immune |
Any time |
PEP not indicated if has documented immunity |
None |
|
Nonimmune |
0 – 6 days |
Immune Globulin Intravenous (IGIV) 400 mg/kg IV (intravenously) |
Quarantine for 28 days after last exposure |
||
|
> 6 days |
PEP not indicated (too late) |
Quarantine for 21 days after last exposure |
Adapted from: Measles | Red Book: 2024–2027 Report of the Committee on Infectious Diseases | Red Book Online | American Academy of Pediatrics and pep-measles-providers.pdf
*IGIM can be given to other persons (e.g., ≥ 12 months of age) who do not have evidence of measles immunity, but priority should be given to persons exposed in settings with intense, prolonged, close contact (e.g., household, childcare, classroom).