Medication Precautions for COVID-19
Medication Precautions |
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Paxlovid (nirmatelvir + ritonavir) |
Remdesivir |
Tocilizumab |
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Kidney Dysfunction |
Not recommended when eGFR < 30 mL/min |
Use with caution when CrCl < 30 mL/min |
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Increased AST or ALT |
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Consider discontinuation if ALT ≥ 10x upper limit of normal |
May cause hepatic injury |
Neutropenia or Thrombocytopenia |
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Warning to avoid for chronic use when ANC < 2000 cells/mm3 or platelets <100,000 per mm3 |
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Drug Interactions |
Elevated drug concentrations are associated with serious and/or life-threatening reactions Link to complete list of drug interactions |
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These pathways do not establish a standard of care to be followed in every case. It is recognized that each case is different, and those individuals involved in providing health care are expected to use their judgment in determining what is in the best interests of the patient based on the circumstances existing at the time. It is impossible to anticipate all possible situations that may exist and to prepare a pathway for each. Accordingly, these pathways should guide care with the understanding that departures from them may be required at times.