Astrolabe is software for translating whole genome sequence data into pharmacogenetic information that can be used to guide medication selection, dosing and prescription. Clinicians and researchers can use this information to reduce adverse drug events and maximize medication efficacy.
Pharmacogenetic allele identification
Ongoing pharmacogenetic research defines drug/gene connections and maps drug response to specific alleles. Gene alleles are defined by specific genetic variants and assigned identifiers that form an allele nomenclature that is used by public and private resources to connect variation to gene activity.
Astrolabe takes genetic variants and sequences generated by whole genome, whole exome and targeted panel sequencing and compares it to the catalog of pharmacogenetic alleles to determine which pair of alleles a patient carries.
Astrolabe was initially developed for the CYP2D6 gene, then extended to CYP2C9 and CYP2C19 with additional genes in the process of being validated. Astrolabe is integrated with the PharmVar (Pharmacogene Variation Consortium) database, a National Institutes of Health-funded project produced as a collaboration between the Children’s Mercy Clinical Pharmacology program and the Center for Pediatric Genomic Medicine.