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Children’s Mercy Research Institute advances pediatric health through integrated, collaborative studies and clinical trials aimed at bringing the fruits of scientific discovery right to a child’s bedside.

Our decades-long participation in pediatric clinical research studies include pediatric pharmacological and drug-therapy trials sponsored by industry, local, and state agencies and the federal government.

Current studies

The purpose of this 12-month study is to confirm the safety of using Dexcom's G6 Mobile CGM System for making diabetes treatment decisions instead of fingerstick testing. Learn more about the study.

A first-of-its-kind pediatric data repository to find novel treatments for pediatric genetic conditions. Learn more about the study

Depression affects many teens and picking the right treatment can be hard. This study will help us learn why certain medicine works for some teens with depression and not for others. Learn more about the study. Learn more about the study

Asthma is a very common disease in children. We know a lot about how to treat asthma. But, we still need better ways to determine which medications work best for each individual child with asthma. This study will tell us if a tool called Histamine Iontophoresis with Laser Doppler monitoring (HILDA) will be able to help us predict if adding a regularly used allergy medicine to a child’s regular asthma treatment regimen will improve their asthma symptoms. Learn more about the study.

Hypophosphatasia is a disease that affects the development of bones and teeth.  Sometimes people appear to have hypophosphatasia, but their molecular testing does not reflect this diagnosis.  The purpose of this research study is to take a deeper look at the genes of people who clinically appear to have the diagnosis of hypophosphatasia but do not have a pathogenic variant to prove their diagnosis. Learn more about the study.

A study to discover individual differences in brain reward activity in teens and young adults with eating disorders. Learn more about the study.

Reaching Out for Epilepsy in Adolescents and Children through Telemedicine (REACT) increases access to quality, coordinated health care for children and youth with epilepsy, specifically for those residing in rural and medically underserved areas in Kansas. Learn more about the study.

A program dedicated to getting families talking with their babies early. Learn more about the study.

Active clinical trials
Clinical trials are an important part of research at Children's Mercy. Each year, our researchers participate in hundreds of clinical trials.

Pioneers Recruitment Registry


The Pioneers Recruitment Registry is a network of hospitals and doctors located in Kansas and Western Missouri seeking volunteers to participate in clinical trials.

Learn about the Pioneers Recruitment Registry.