Cannabinoid Hyperemesis Syndrome

Clinical Pathways promote evidence-based, safe, and high-value patient care by providing clinical recommendations and standard processes. They are developed by multidisciplinary committees of subject matter experts, informed by a methodical review of available evidence and consensus among committee members.  

Clinical Pathway: 

• Cannabinoid Hyperemesis Syndrome Algorithm 
  • Includes:
    • Initial Screening and Management Algorithm
    • Treatment Algorithm 

• Cannabinoid Hyperemesis Syndrome Synopsis (provides care standards employed for this clinical pathway)

Additional tools associated with this Clinical Pathway:

• Cannabinoid Hyperemesis Syndrome: Information for Patients and Caregivers   

Inclusion and exclusion criteria: 

• Inclusion:
  • Patients presenting with concern for CHS  

• Exclusion: 
  • Patients less than 12 years of age 
  • Pregnancy 
  • Concern for sepsis (see Sepsis pathway) 
  • Concern for acute abdomen 

Committee members involved in the development: 

• Frances Turcotte-Benedict, MD, MPH, FAAP | Emergency Department | Committee Chair 
• Micheal Christian, MD | Clinical Pharmacy and Toxicology | Committee Member 
• Jonathan Hartley, DO | Hospital Medicine | Committee Member 
• Sarah Lee, LCSW, LSCSW | Social Work | Committee Member 
• Carson Savrick, MS, MD | Emergency Medicine Fellow | Committee Member 
• Smit Shah, MD | Hospital Medicine Fellow | Committee Member 
• Ibad Siddiqi, PharmD | Pharmacy | Committee Member 
• Catherine Watts, MD | Urgent Care | Committee Member 
• Thomas Attard, MD, FAAP, FACG | Gastroenterology | Contributor 
• Sarah Edwards, DO | Gastroenterology | Contributor
• Brianne Shuler, MD | Gastroenterology | Contributor 

EBP Committee Members: 

• Todd Glenski, MD, MSHA, FASA | Anesthesiology, Evidence Based Practice 
• Megan Gripka, MPH, MLS (ASCP) SM | Evidence Based Practice 

Publication dates: 

• Finalized date: 05/2026 
• Next expected revision date: 05/2026 

Concerns with content: 

If you have any questions regarding this content or identify a broken link, please email evidencebasedpractice@cmh.edu.  

These pathways do not establish a standard of care to be followed in every case. It is recognized that each case is different, and those individuals involved in providing health care are expected to use their judgment in determining what is in the best interests of the patient based on the circumstances existing at the time. It is impossible to anticipate all possible situations that may exist and to prepare a pathway for each. Accordingly, these pathways should guide care with the understanding that departures from them may be required at times.