Research Studies and Clinical Trials Search
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Phentermine's Impact on Treatment in Teens (PhITT): A study of Phentermine for Adolescents with Obesity
This study is being done for teenagers: • Age 12 to 17 years old by enrollment time • Body Mass Index (BMI) greater than...
This study is being done for teenagers: • Age 12 to 17 years old by enrollment time • Body Mass Index (BMI) greater than or equal to 30, or greater than or equal to the 95th percentile. • Able to attend a clinic visit every 4 weeks, for a total of 16 visits Researchers are looking for teenagers to volunteer for a research study using the drug phentermine. Researchers hope to find out if phentermine is safe and effective for weight loss in younger teens and for a longer period of time. There is no cost to be in the study
Single Ventricle Condition: A Clinical Trial of a Medication to Increase Exercise Endurance for Adolescents who had a Fontan Procedure
This study is for children: • Age 12-18 years old • Born with a single ventricle and had a Fontan procedure • Currently on blood thinner (i.e. taking medications such as aspirin, heparin, coumadin/warfarin, etc.)...
This study is for children: • Age 12-18 years old • Born with a single ventricle and had a Fontan procedure • Currently on blood thinner (i.e. taking medications such as aspirin, heparin, coumadin/warfarin, etc.) The purpose of this study is to find out if the investigational study drug, udenafil, is effective and safe in adolescent participants who have single ventricle heart disease (SVHD) and have undergone a Fontan procedure. Udenafil works to help dilate (open) the blood vessels, which allows for better function of the heart and lungs. The study aims to (1) find out how well udenafil works to improve a patient's ability to exercise and perform everyday activities (2) potentially prevent liver fibrosis, a common complication of SVHD. Patients who participate in the study will be randomly assigned, like flipping of a coin, to receive either udenafil or placebo (does not contain active medication) and have an equal chance (50%) of receiving either udenafil or placebo. Participants will take one tablet by mouth, twice a day, for 26 weeks and be in the study for approximately 7 months.
Single Ventricle Heart Condition: How Skeletal Muscle Health Contributes Toward Overall Health
This study is for children: • 12-18 years old • Born with a single ventricle heart and had the Fontan Procedure • Be able to wear an accelerometer for a week. (Accelerometer is a small device worn on the hip to measure physical...
This study is for children: • 12-18 years old • Born with a single ventricle heart and had the Fontan Procedure • Be able to wear an accelerometer for a week. (Accelerometer is a small device worn on the hip to measure physical activity) OR • 12-18 years old • Born with a normal heart (comparison group) • Be able to wear an accelerometer for a week. (Accelerometer is a small device worn on the hip to measure physical activity) The goal of the research study is to better understand the importance of skeletal muscle health (especially leg muscles) and how it contributes to the overall health of an adolescent living with a single ventricle heart. Researchers know that healthy muscles play a larger role in helping blood return to the lungs in these adolescents, but they do not understand the details of this relationship. In addition, adolescents with normal hearts will be enrolled as a comparison group.
The Remote CaRe CHD Trial: An in-home exercise study for teens with congenital heart disease
This study is for: • Adolescents, aged 12-19 years old • Diagnosed with either: Fontan physiology, Tetralogy of Fallot, or D-Transposition of the great arteries...
This study is for: • Adolescents, aged 12-19 years old • Diagnosed with either: Fontan physiology, Tetralogy of Fallot, or D-Transposition of the great arteries Most patients and families with congenital heart disease (CHD) have little or no access to a supervised cardiac rehabilitation program specifically designed for teens with CHD. The Remote CaRe CHD Trial is studying the effects of a 12-week supervised exercise program delivered IN YOUR HOME using live video conferencing software - allowing everyone to have access to exercise training specifically for teens with CHD. Researchers aim is to see if the in-home, Remote CaRe exercise program can increase fitness, physical function, and quality of life in teens with CHD. To learn more, you can watch the Remote CaRe video by copying/pasting this link into your browser: https://youtu.be/WO4JEpXOZDM?si=psbhbtUre5nW9SDf You can call or text us at 816-764-5605 or you can email us at remotecare@cmh.edu