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Pediatric Clinical Pharmacology and Medical Toxicology

Educational objectives:

  • Develop a working knowledge of developmental physiology and pathophysiology and their impact on the pharmaco/toxicokinetics and pharmacodynamics of commonly used medications in pediatrics. 

  • Develop a working knowledge of therapeutic drug monitoring (TDM) and clinical pharmacokinetics and it's application as a therapeutic tool in pediatric practice. 

  • Acquire a working knowledge of the principles underlying pharmacodynamics (drug action), adverse drug reactions and drug interactions, and how they impact pharmacotherapeutic decision making. 

  • Integrated approach to drug therapy which embraces both science (i.e., biochemistry, pharmacology, pharmacokinetics) and clinical science (i.e., pathophysiology, developmental biology) in process (i.e., drug selection) and outcome (i.e., assessment of safety and efficacy). 

Responsible faculty: D. Adam Algren, MD (aalgren@cmh.edu)

Contact person: April Gerry, BS (algerry@cmh.edu), (816) 234-1367

Elective duration: One month

Maximum enrollment: One

Format: Interaction with division staff, lectures, consultations.

Prerequisites: Interview with Dr. Lowry is required prior to approval of rotation.

Description: Acquire a working knowledge of pediatric toxic exposures (i.e., drugs, plants, household chemicals, substances of abuse, venomous bites and stings, antidotes, hazardous materials) and their management. To develop skills in the areas of drug and poison information retrieval and interpretation, which are relevant to the areas of Clinical Pharmacology and Therapeutic Innovation. To acquire an understanding of the functioning of a poison control center. To acquire a rudimentary working knowledge of clinical investigation and how to interpret scientific data (i.e., published literature, analytical laboratory results) in the context of clinical experience of students in conformity with their needs, interests and/or future professional plans.

Calls: No

Criteria for passing: Satisfactory performance on the clinical evaluation. 

Criteria for honors: Outstanding performance on the clinical evaluation.