- Magnesium (IV)
- 50 mg/kg (maximum 2 grams)
A strong recommendation is made to consider magnesium sulfate (IV) for the patient with a severe asthma exacerbation, or an exacerbation that does not respond to initial treatment in the ED. The effect is well studied in adults and is graded as high-quality evidence. In adults, administration of magnesium sulfate (IV) has been shown to reduce hospital admission. However, for children, the evidence is low quality due to inconsistency of the magnesium sulfate doses used in only three studies. However, in most asthma guidelines, including GINA (2018), the governing guideline of this CPG, children greater than 6 years of age are treated as adults. GINA (2018) recommends considering magnesium (IV) for severe asthma exacerbations, or those that do not respond to conventional treatment.
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GINA. (2018). Global Strategy of Asthma Management and Prevention.