- Prednisone/Prednisolone – 2 mg/kg (maximum 60 mg)
- Dexamethasone (oral) – 0.6 mg/kg (maximum 12 mg), for 1 or 2 days)
- Methylprednisolone (IV) – 2 mg/kg (maximum 60 mg)
CSs have similar efficacy, and short-term adverse events outcomes are not found in otherwise healthy children (Fernandes et al., 2014). Long term adverse events (such as hypertension, adrenal suppression) outcomes are poorly studied. The decision to select one or another for treatment may be based on compliance to treatment and adverse events including (a) vomiting in the ED, (b) vomiting at home, and (c) adrenal suppression in children with frequent asthma exacerbations. No studies were identified that evaluated these as primary outcomes.
For additional information click here for the Oral Dexamethasone vs. Prednisone for a Pediatric Asthma Exacerbation Critically Appraised Topic (CAT), or here for more informtation on the Dose of Glucocorticosteroids for Asthma in the ED/UCC.
Fernandes, R. M., Oleszczuk, M., Woods, C. R., Rowe, B. H., Cates, C. J., & Hartling, L. (2014). The Cochrane Library and safety of systemic corticosteroids for acute respiratory conditions in children: an overview of reviews. Evid Based Child Health, 9(3), 733-747. doi:10.1002/ebch.1980