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GOLDILOKS GOLDILOKS Clinic

The GOLDILOKS® Clinic at Children's Mercy Kansas City is designed to serve as a multi-disciplinary resource in therapeutics for patients and providers within the region. This clinic will serve patients with complex therapeutic dilemmas who are referred by their primary care physician or sub-specialist. 

Clinic Staff

This clinic will implement a team approach to address the facets of therapeutic response that are unique to each patient. This will include a weekly comprehensive case discussion of each patient with a team of physicians, researchers and pharmacists. Recommendations may include follow-up, adjustments to the care plan and/or additional testing.

Common Conditions Treated

Our team provides care for patients who meet the following criteria:

Lack of response to a medication despite being prescribed a standard drug dose. This may be addressed with a variety of evaluations:

  • Clinical pharmacology evaluation of absorption, distribution and excretion
  • Evaluation of drug-drug (drug-diet, drug-disease, drug-development) interactions
  • Evaluation of genomic variants known to affect drug metabolism and drug response via clinically available testing
  • Assessment of underlying etiology of patient's condition with respect to therapeutic response

Drug side effects

  • Toxicities associated with overdose despite "appropriate" drug dose 
    • Examples: excessive sedation, excessive nausea
    • Help to establish correct medicine at correct dose for patient's specific condition
    • Help predict "personalized drug of choice"
  • Idiosyncratic drug reactions (reaction to a medication with an unknown cause)
  • "Hypersensitivity" reactions 
    • Collaborative Evaluation with appropriate specialties - dermatology, allergy, organ-specific evaluation, depending on nature of reaction

Examples of patients already referred to the GOLDILOKS® Clinic

  • Patient with ADHD who fail to respond clinically to therapeutic treatment as standard dosing
  • Unexplained adverse reaction to cough medication
  • Patients with unusual reactions to multiple medications

Family Evaluation

  • Assessment of pharmacogenomic variation which may be clinically significant in family members of patients with therapeutic enigmas that have been determined to be related to genetic variation

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