More on normalization (July 28, 2005)

I am looking into a variety of ways to normalize a set of microarrays from Affymetrix. The concept is similar to normalization for a two-dye array, but there are some subtle differences also. A good reference for normalization methods is

• A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bolstad BM, Irizarry RA, Astrand M, Speed TP. Bioinformatics. 2003 Jan 22;19(2):185-93. [Medline] [PDF].

This webpage was written by Steve Simon and was last modified on 07/08/2008.