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Case cohort design (August 11, 2005).

During a consultation about an NIH research grant, the term "case cohort design" came up. The Case Cohort design is similar to a nest Case Control design, but also has some important differences.

Here are two published examples of a Case Cohort design:

  • Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins: the Atherosclerosis Risk in Communities (ARIC) study. Folsom AR, Nieto FJ, McGovern PG, Tsai MY, Malinow MR, Eckfeldt JH, Hess DL, Davis CE. Circulation 1998: 98(3); 204-10. [Medline] [Abstract] [Full text] [PDF]
  • Risk of upper aerodigestive tract cancers in a case-cohort study of autoworkers exposed to metalworking fluids. Zeka A, Eisen EA, Kriebel D, Gore R, Wegman DH. Occup Environ Med 2004: 61(5); 426-31. [Medline] [Abstract] [Full text] [PDF]

And here are four published examples of a Nested Case Control design:

  • Benign breast disease, recent alcohol consumption, and risk of breast cancer: a nested case-control study. Tamimi RM, Byrne C, Baer HJ, Rosner B, Schnitt SJ, Connolly JL, Colditz GA. Breast Cancer Res 2005: 7(4); R555-62. [Medline] [Abstract] [Full text] [PDF]
  • Abdominal fat and hip fracture risk in the elderly: the Dubbo Osteoporosis Epidemiology Study. Nguyen ND, Pongchaiyakul C, Center JR, Eisman JA, Nguyen TV. BMC Musculoskelet Disord 2005: 6(1); 11. [Medline] [Abstract] [Full text] [PDF]
  • Relation of childhood gastrointestinal disorders to autism: nested case-control study using data from the UK General Practice Research Database. Black C, Kaye JA, Jick H. Bmj 2002: 325(7361); 419-21. [Medline] [Abstract] [Full text] [PDF]
  • Familial, psychiatric, and socioeconomic risk factors for suicide in young people: nested case-control study. Agerbo E, Nordentoft M, Mortensen PB. Bmj 2002: 325(7355); 74. [Medline] [Abstract] [Full text] [PDF]

When I get the time, I will prepare a formal definition of these two terms.

This webpage was written by Steve Simon and was last modified on 2008-07-14. Send feedback to ssimon at cmh dot edu or click on the email link at the top of the page. Category: Observational studies