Interesting article: Visual inspection with acetic acid as a cervical cancer test: accuracy validated using latent class analysis. Lynne Gaffikin , John A McGrath , Marc Arbyn and Paul D Blumenthal. BMC Medical Research Methodology 2007, 7:36 doi:10.1186/1471-2288-7-36. [Abstract] [PDF] Description: Estimating sensitivity and specificity is difficult when you have an imperfect gold standard to compare to the diagnostic test. Typically this causes biases that make sensitivity and specificity too large. This article shows an example of latent class analysis as a solution to this problem. The description of this article was written on 2007-08-07, 2008-01-12. Category: Diagnostic testing, Category: Interesting articles