Research Steven J. Leeder, Pharm.D., Ph.D.
Research Steven J. Leeder, Pharm.D., Ph.D.

Steven J. Leeder, Pharm.D., Ph.D.

Marion Merrell Dow/Missouri Endowed Chair in Pediatric Clinical Pharmacology
Director, Division of Clinical Pharmacology and Therapeutic Innovation

Dr. Leeder is currently the Marion Merrell Dow/Missouri Endowed Chair in Pediatric Clinical Pharmacology and Director of the Division of Clinical Pharmacology and Therapeutic Innovation at Children’s Mercy. He holds professorial appointments at the University of Missouri-Kansas City, University of Kansas (Lawrence, KS) in Pharmaceutical Chemistry and the University of Kansas Medical Center (Kansas City, KS) in Pharmacology, Toxicology and Therapeutics. 

Dr. Leeder’s service to the discipline of Clinical Pharmacology includes past memberships as Chair of the Drug Metabolism Division of the American Society for Pharmacology and Experimental Therapeutics (ASPET) and Treasurer of the Drug Metabolism Section of the International Union of Basic and Clinical Pharmacology (IUPHAR). Over the past 30 years, Dr. Leeder’s research has produced over 160 peer-reviewed publications which include highly cited reviews on the application of pharmacogenetic and pharmacogenomic strategies to observe variability in drug disposition and response in children. He has received continuous research support from the Medical Research Council of Canada and NIH since 1993.

Research Interests

  • Pediatric Clinical Pharmacology
  • Pediatric Pharmacogenetics
  • Developmental Pharmacogenomics
  • Adverse Drug Reactions
PubMed publications »

Education and Training

  • 1980 University of Toronto, Toronto, Ontario (B.Sc.Phm in Pharmacy)
  • 1982 University of Minnesota, Minneapolis, MN (Pharm.D. in Pharmacy)
  • 1989 University of Toronto, Toronto, Ontario (Ph.D. in Pharmacology)

Professional Experience

  • 1982 to 1984 Research Institute, The Hospital for Sick Children, Toronto, Ontario (Fellowship in Clinical Pharmacology) 
  • 1984 to 1989 Research Institute, The Hospital for Sick Children, Toronto, Ontario (Fellowship in Clinical Pharmacology and Toxicology)
  • 2000 to 2008 Chief, Section of Developmental Pharmacology and Experimental Therapeutics, Children’s Mercy, Kansas City, MO
  • 2002 – Professor, Pediatrics and Pharmacology, University of Missouri-Kansas City, Kansas City, MO
  • 2003 to 2008 Marion Merrell Dow Endowed Chair in Pediatric Pharmacogenomics, The Children’s Mercy, Kansas City, MO
  • 2004 – Adj. Prof. of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS
  • 2008 – Marion Merrell Dow/Missouri Chair in Pediatric Pharmacology, Children’s Mercy, Kansas City, MO
  • 2008 – Director, Division of Clinical Pharmacology and Therapeutic Innovation, Children’s Mercy, Kansas City, MO 
  • 2008 – Marion Merrell Dow-Missouri Endowed Chair in Pediatric Clinical Pharmacology, Children’s Mercy, Kansas City, MO 
  • 2008 – Adjunct Professor of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS

Active Extramural Research Support

1 R01 HD058556-04 Leeder (PI) 04/01/10 – 02/28/15
National Institutes of Health (NICHD)
Exogenous and endogenous biomarkers of CYP2D6 variability in pediatrics

2 R13 HD065386-03 Leeder (PI) 04/01/12 – 03/31/14
National Institutes of Health (NICHD)
Pediatric Pharmacogenomics and Personalized Medicine

1 T32 HD069038-02 Kearns GL (PI) / Leeder JS (Associate Program Director) 07/01/11 – 6/30/16
National Institutes of Health (NICHD)
Research Fellowship Program in Pediatric Clinical/Developmental Pharmacology

1 UL1 RR 033179-02 Barohn R and Aronson L (PI) / Leeder JS (Associate Director) 07/01/11 – 06/30/16
NIH-NCRR
Heartland Institute for Clinical and Translational Research (HICTR)

No grant # Abdel-Rahman SM (PI) / Leeder JS (Co-I) 07/01/11 - 06/30/13
Gerber Foundation
Using Genetic Predictors of Neonatal Hyperbilirubinemia to Transform the Care of Newborns

R01 HD060559-04 Yost G (PI) / Leeder JS (Co-I) 12/1/09 – 11/30/14
National Institutes of Health (NICHD)
P450 Metabolism of Glucocorticoids in Lungs of Pediatric Asthmatics

1 R01 HL097144-04 Weiss ST and Kobzik L (PI) / Leeder JS (Sub-contract PI) 09/1/09 – 07/31/14
National Institutes of Health (NHLBI)
Intrauterine Smoke Exposure and Asthma: Genomic Origins

1 R01GM088076-04 Skaar T (PI) / Leeder JS (Co-I) 09/30/09 – 08/31/13
National Institutes of Health (NICHD)
Regulation of Drug Metabolizing Enzymes by miRNAs

HHSN201000003I Benjamin D (PI) / Leeder JS (Co-Chair) 10/1/10 – 09/30/17
National Institutes of Health (NICHD)/ Best Pharmaceuticals for Children Act (BPCA)
Pediatric Trials Network

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