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Asthma Synthesized Literature

What is the prognostic ability of saturated oxygen values for guiding treatment of children with acute asthma in the ED?

What level of oxygen saturation was used as a cutoff for subjects in studies of asthma exacerbations?

In the child with asthma exacerbation in the ED should epinephrine be used? 

In the child with asthma exacerbation in the ED should albuterol with ipratropium vs. albuterol alone be used to prevent hospitalization, decrease time in the ED, and improve pulmonary function?

In the child with asthma exacerbation in the ED should magnesium sulfate IV be used prevent hospitalization, decrease time in theED, and improve pulmonary function?

In the child with asthma exacerbation in the ED, should helioxdriven albuterol vs. oxygen or room air driven albuterol be used to prevent hospitalization, decrease time in the ED or improve pulmonary function?

In the child with a mild to moderate asthma exacerbation in the ED should albuterol be administered by nebulizer or multi-dose inhaler (MDI) and spacer to prevent hospitalization, decrease time in the ED or improve pulmonary function?

In the child with asthma exacerbation in the ED should prednisolone/prednisone vs. dexamethasone be used to prevent hospitalization, decrease time in the ED or improve pulmonary function? 

In the child with asthma exacerbation in the ED, should inhaled steroids be started during an asthma exacerbation to prevent hospitalization, decrease time in the ED, and improve pulmonary function or to prevent rebound trips to the ED or other healthcare providers?

In the child with asthma exacerbation in the ED should CPAP or BiPap be used prevent hospitalization, decrease time in the ED, and improve pulmonary function?

In the child with asthma exacerbation in the ED should montelukast IV be used prevent hospitalization, decrease time in the ED, and improve pulmonary function?

What is the efficacy of a common container metered-dose inhaler (MDI) when treating asthma exacerbation in the emergency department?


These guidelines do not establish a standard of care to be followed in every case. It is recognized that each case is different and those individuals involved in providing health care are expected to use their judgment in determining what is in the best interests of the patient based on the circumstances existing at the time. It is impossible to anticipate all possible situations that may exist and to prepare guidelines for each. Accordingly these guidelines should guide care with the understanding that departures from them may be required at times.

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