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Annotations Potential Drug Interactions

Potential drug interactions

  • Increased potential for hemorrhage:
    • Thrombolytic agents-urokinase, streptokinase, and alteplase.
    • Drugs affecting platelet function-aspirin, NSAIDs, dipyridamole, clopidogrel, ticlopidine & cilostazol.
    • Complementary/alternative medications known to have potential to increase bleeding include danshen, devil's claw, dong quai, feverfew, gingko biloba and papain.
  • Decreased effect of heparin :
    • Digoxin, tetracycline, nicotine, antihistamines, and IV nitroglycerin.


These guidelines do not establish a standard of care to be followed in every case. It is recognized that each case is different and those individuals involved in providing health care are expected to use their judgment in determining what is in the best interests of the patient based on the circumstances existing at the time. It is impossible to anticipate all possible situations that may exist and to prepare guidelines for each. Accordingly these guidelines should guide care with the understanding that departures from them may be required at times.

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