Researchers tailor the use of medications to the unique needs of individual pediatric patients. The goal of the Clinical Pharmacology research program is to explore the extent of variability in the response to medications across all fields of pediatric medicine, and to learn about the relative contributions of genetics and development to the observed variability. The ultimate goal of the program is to improve clinical care by increasing both the safety and effectiveness of medications in children. A secondary goal is to provide a learning environment conducive to developing clinician-scientists committed to improving the use of medications in children.

Areas of Activity

• Adverse drug reactions
• Personalized Medicine for children
• Experimental therapy in pediatric Hematology/Oncology
• Developmental pharmacokinetics and pharmacodynamics
• Bioinformatics and intelligent computing
• Drug disposition and action in the neonate
• Pharmacogenetics of drug metabolism and disposition
• Impact of development on drug metabolism
• Genotype/phenotype associations in asthma
• Development of pharmacodynamic biomarkers
• Systemic responses to spider poisoning