Pharmacology and Toxicology 2011 Research
Pharmacology and Toxicology 2011 Research

Peer-Reviewed Articles

Abdel-Rahman SM, Chandorkar G, Akins RL, Bradley JS, Jacobs RF, Donovan J, Benziger DP. Single-dose pharmacokinetics and tolerability of daptomycin 8 to 10 mg/kg in children aged 2 to 6 years with suspected or proved Gram-positive infections. Pediatr Infect Dis J 30: 712-714 (2011)

Abdel-Rahman SM, Newland JG, Kearns GL. Pharmacologic considerations for oseltamivir disposition: Focus on the neonate and young infant. Paediatr Drugs 13: 19-31 (2011)

Algren DA, Lowry JA, Wasserman GS. Pearls about loxoscelism. Ann Emerg Med 57: 419-420 (2011)

Al-Khamees WA, Schwartz MD, Alrashdi S, Algren AD, Morgan BW. Status epilepticus associated with borage oil ingestion. J Med Toxicol 7: 154-157 (2011)

Becker M, Gaedigk R, van Haandel L, Thomas B, Lasky A, Hoeltzel M, Dai H, Stobaugh J, Leeder J. The effect of genotype on methotrexate polyglutamate variability in juvenile idiopathic arthritis and association with drug response. Arthritis Rheum 63: 276-285 (2011)

Feng Q, Kalari K, Fridley BL, Jenkins G, Ji Y, Abo R, Hebbring S, Zhang J, Nye MD, Leeder JS, Weinshilboum RM. Betaine-homocysteine methyltransferase: Human liver genotype-phenotype correlation. Mol Genet Metab 102: 126-133 (2011)

Gaedigk A, Hernandez J, Garcia-Solaesa V, Sanchez S, Isidoro-Garcia M. Detection and characterization of the CYP2D6*9x2 gene duplication in two Spanish populations: Resolution of AmpliChip CYP450 test no-calls. Pharmacogenomics 12: 1617-1622 (2011)

Gaedigk A, Twist GP, Leeder JS. CYP2D6, SULT1A1 and UGT2B17 copy number variation: Quantitative detection by multiplex PCR. Pharmacogenomics 13: 91-111 (2011)

Goldman J, Becker ML, Jones B, Clements M, Leeder JS. Development of biomarkers to optimize pediatric patient management: What makes children different? Biomarkers Med 5(6): 781-794 (2011)

Goldman JL, Kearns GL, Abdel-Rahman S. Pharmacologic Considerations Antitubercular Agents in Children. Prog Respir Res 40: 1-15 (2011)

Goldman J, Becker ML, Jones B, Clements M, Leeder JS. Development of biomarkers to optimize pediatric patient management: What makes children different? Biomark Med 5:781-94 (2011)

Humphrey A, Dalal J, Jones B. Omenn's syndrome manifests via novel genotype and phenotype. Annals of Allergy, Asthma & Immunology 5: 160 (2011)

Jones BL. The impact of pharmacogenetics in the treatment of allergic disease and asthma. Mo Med 108: 361-365 (2011) 

Kearns GL. Beyond biomarkers: An opportunity to address the 'pharmacodynamic gap' in pediatric drug development. Biomark Med 4: 783-786 (2011)

Lowry JA, Garg U. Serum concentrations in three children with unintentional tetrahydrozoline overdose. Clin Toxicol 49: 434-435 (2011)

Madadi P, Ciszkowski C, Gaedigk A, Leeder JS, Teitelbaum R, Chitayat D, Koren G. Genetic transmission of cytochrome P450 2D6 (CYP2D6) ultrarapid metabolism: implications for breastfeeding women taking codeine. Curr Drug Saf 6: 36-39 (2011)

McCarver G, Bhatia J, Chambers C, Clarke R, Etzel R, Foster W, Hoyer P, Leeder JS, Peters JM, Rissman E, Rybak M, Sherman C, Toppari J, Turner K. NTP-CERHR expert panel report on the developmental toxicity of soy infant formula. Birth Defects Res B Dev Reprod Toxicol 92: 421-468 (2011)

Melen E, Kho AT, Sharma S, Gaedigk R, Leeder JS, Mariani TJ, Carey VJ, Weiss ST, Tantisira KG. Expression analysis of asthma candidate genes during human and murine lung development. Respir Res 12: 86 (2011)

Mikkelsen TS, Thorn CF, Yang JJ, Ulrich CM, French D, Zaza G, Dunnenberger HM, Marsh S, McLeod HL, Giacomini K, Becker ML, Gaedigk R, Leeder JS, Kager L, Relling MV, Evans W, Klein TE, Altman RB. PharmGKB summary: methotrexate pathway. Pharmacogenet Genomics 21: 679-686 (2011)

Milesi-Halle A, Abdel-Rahman SM, Brown A, McCullough SS, Letzig L, Hinson JA, James LP. Indocyanine green clearance varies as a function of N-acetylcysteine treatment in a murine model of acetaminophen toxicity. Chem Biol Interact 189: 222-229 (2011)

Miller K, Silvey M, Logsdon D, Balch F, Nsumu N, Sokolovsky I, Gibson M, Bi C, Heruth D, White RA. The Xla (X-linked anemia) mouse: A transient neonatal anemia caused by a Gata1 splicing mutation. Blood 1366-1367 (2011)

Neville KA, Becker ML, Goldman JL, Kearns GL. Developmental pharmacogenomics. Paediatr Anaesth 21: 255-265 (2011)

Price KE, Pearce RE, Garg UC, Heese BA, Smith LD, Sullivan JE, Kennedy MJ, Bale JF, Jr., Ward RM, Chang TK, Abbott FS, Leeder JS. Effects of valproic acid on organic acid metabolism in children: a metabolic profiling study. Clin Pharmacol Ther 89: 867-874 (2011)

Shimizu M, Denton T, Kozono M, Cashman JR, Leeder JS, Yamazaki H. Developmental variations in metabolic capacity of flavin-containing mono-oxygenase 3 in childhood. Br J Clin Pharmacol 71: 585-591 (2011)

Sibley T, Algren DA, Ellison S. Bilateral patellar tendon ruptures without predisposing systemic disease or steroid use: a case report and review of the literature. Am J Emerg Med 30: 261 e3-5 (2011)

Sithisarn T, Bada HS, Dai H, Randall DC, Legan SJ. Effects of perinatal cocaine exposure on open field behavior and the response to corticotropin releasing hormone (CRH) in rat offspring. Brain Research 1370: 136-144 (2011)

Thorn CF, Leckband SG, Kelsoe J, Leeder JS, Muller DJ, Klein TE, Altman RB. PharmGKB summary: Carbamazepine pathway. Pharmacogenet Genomics 21: 906-910 (2011)

van Haandel L, Becker ML, Williams TD, Leeder JS, Stobaugh JF. Measurement of methotrexate polyglutamates in human erythrocytes by ion-pair UPLC-MS/MS. Bioanalysis 3: 278327-96 (2011)

Wang X, Nanovskaya TN, Zhan Y, Abdel-Rahman SM, Jasek M, Hankins GD, Ahmed MS. Pharmacokinetics of metronidazole in pregnant patients with bacterial vaginosis. J Matern Fetal Neonatal Med 24: 444-448 (2011)

Book or Book Chapters

Garg U, Sandritter TL, Leeder JS. Pediatric Therapeutic Drug Monitoring in Toxicology and Pharmacogenomics, in Biochemical and Molecular Basis of Pediatric Disease, 4th Edition, Wong E, Bennett M, DietzenD, (edS.), American Association for Clinical Chemistry, Washington DC (2011)

Goldman JL, Kearns GL, M. A-RS. Pharmacological considerations of antitubercular agents in children, Chapter 17, in Antituberculosis Chemotherapy. Donald PR,van Helden PD (eds.), Karger, Basel, New York, NY, pp. 161-175 (2011)

James L, Lowry J, Palmer K, O'Brien C, Farrar H, Kearns G. Gastrointestional Drugs in Neonatal and Pediatric Pharmacology: Therapeutic Principles in Practice, 4th Edition Edition, Yaffe SaAJ (ed.), Lippincott, Williams and Wilkins, New York, NY, pp.742-759 (2011)

Lowry J, Jones B, Sandritter T, Liewer S, Kearns GL. Principles of Drug Therapy, Chapter 57, in Nelson Textbook of Pediatrics, 19th Edition, Kliegman RM, Behrman RE, Jenson HB,Stanton BMD (eds.), Elsevier, Philadelphia, PA (2011)

Neville KA, Leeder JS. Pediatric Pharmacogenetics and Pharmacogenomics, Chapter 56, in Nelson Textbook of Pediatrics, 19th Edition, Kliegman RM, Behrman RE, Jenson HB,Stanton BMD (eds.), Elsevier, Philadelphia, PA (2011)

Scientific Presentations-Oral or Poster Format

Abdel-Rahman SM "Developmental Pharmacology for the Practicing Pediatrician " Department of Pediatrics, Sardar Vallab bhai Patel Post Graduate Institute of Paediatrics, S.C.B Medical College, Cuttack, India, February 2011 [Oral]

Abdel-Rahman SM "When Efficacy and Effectiveness Diverge: Lessons Learned from Dermatophyte Fungi" American Society for Clinical Pharmacology and Therapeutics (ASCPT), Dallas, TX, March 2011 [Oral]

Abdel-Rahman SM "Pediatric Pharmacokinetics: Understanding the Dose-Exposure Relationship" Malaria Research and Training Center, Universite de Bamako, Bamako, Mali, August 2011 [Oral]

Abdel-Rahman SM "Taking the Guesswork Out of Pediatric Weight Estimation" Gabriel Toure Hospital, Bamako, Mali, August 2011 [Oral]

Abdel-Rahman SM "Paediatric Formulations: The "A" in ADME" European Paediatric Formulation Initiative (EuPFi), Strasbourg, France, September 2011 [Oral]

Abdel-Rahman SM "Developmental Pharmacology: The "A" in ADME" U.S. Pediatric Formulations Initiative, Washington DC, October 2011 [Oral]

Abdel-Rahman SM "Considering the Influence of Anatomy and Physiology in Developing Formulations for Children" Institute for Pediatric Innovation (IPI), Washington, DC, November 2011 [Oral]

Algren A "Clinical and Ancillary Data in Children with Brown Recluse Envenomation " North American Congress of Clinical Toxicology, Washington DC, September 2011 [Oral]

Algren A "Acute Acepromazine Overdose: Clinical Effects and Toxicokinetic Evaluation" North American Congress of Clinical Toxicology, Washington DC, September 2011 [Poster]

Becker ML, van Haandel L, Talib N, Lasky A, Hoeltzel MF, Leeder JS "Intracellular Folate Concentrations in Down Syndrome Patients with Arthritis" ACR/ARHP Pediatric Rheumatology Symposium (PRYSM), Miami, FL, June 2011 [Poster]

Berard A, Karam F, Sheehy O, Huneau MC, Blais L, Briggs G, Roth M, Chambers C, Einarson A, Gaedigk A, et al "Relapse of Depressive and Anxiety Symptoms, and Quality of Life in Pregnant Users and Discontinued Users of Antidepressants: Results from the OTIS Antidepressants Study" The European Network Teratology Information Services (ENTIS)/OTIS, Israel, March 2011 [Poster]

Bi C "Tackling the Challenging Motif Problem Through Hybrid Particle Swarm Optimized Alignment Clustering" Institute of Electrical and Electronics Engineers (IEEE), Paris, France [Oral]

Bi C, Becker ML, Leeder JS "Derivation of Minimum Best Sample Size from Microarray Data Sets: A Monte Carlo Approach" Institute of Electrical and Electronics Engineers (IEEE), Paris, France [Oral]

Fox E, Gibson M, Zhang LQ, Ye SQ, Leeder JS, Becker ML "Decreased Expression of Nicotinamide Phosphoribosyltransferase (NAMPT) in Active Juvenile Idiopathic Arthritis Patients Receiving Methotrexate" American College of Rheumatology, Chicago, IL, November 2011 [Oral]

Gaedigk A "Translating Genotype to Phenotype: Genetic Variability of DMEs" Great Lakes Drug Metabolism, Madison, WI, May 2011 [Oral]

Gaedigk A "Challenges of CYP2D6 Pharmacogenetics and Phenotype Prediction" Center for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada, June 2011 [Oral]

Gaedigk A "Translating Genotype to Phenotype: Genetic Variability of DMEs" International Society for the Study of Xenobiotics (ISSX), Atlanta, GA, October 2011 [Oral]

Gaedigk A, Twist GP, Ndjountsche L, Leeder JS "Detection of CYP2D6, SULT1A1 and UGT2B17 Copy Number Variation (CNV) Using Multiplex PCR Amplification" Experimental Biology (ASPET), Washington DC, April 2011 [Poster]

Goldman JL, Leeder JS, Jackson MA “Long Recognized but Possibly Forgotten – Adverse Reactions to Trimethoprim-Sulfamethoxazole (TMP-SMX)” Infectious Diseases Society of America (IDSA), Boston, MA, October 2011 [Poster]

Goldman JL, Davis HM, Zhou H, Kearns GL “Association of Infliximab Clearance and Resting Energy Expenditure in Children” American Society for Clinical Pharmacology and Therapeutics (ASCPT), Dallas TX, March 2011 [Poster]

Goldman JL, Davis HM, Zhou H, Kearns GL “Association of Infliximab Clearance and Resting Energy Expenditure in Children” American Society for Clinical Pharmacology and Therapeutics (ASCPT), Dallas TX, March 2011 [Oral]

Goldman JL “Congenital Herpes Simplex Virus Infection” Infectious Diseases Society of America (IDSA), Boston, MA, October 2011 [Oral]

Leeder JS "Drug Biotransformation and Pharmacogenomics and CVhildren" Sumner J. Yaffe Memorial Lecture in Pediatric Clinical Pharmacology, Eunice Kennedy Shriver National Institute of Child Health and Human Development webinar, Kansas City, MO, October 2011 [Oral]

Leeder JS "Phenotyping Pathways: Application to Pediatric Pharmacogenomics" Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, August 2011 [Oral]

Leeder JS "Relating Pathway Phenotypes to Variability in Drug Disposition and Response in Children" College of Pharmacy, University of Illinois Chicago, Chicago, IL, August 2011 [Oral]

Leeder JS "The Cytochrome P450 System in Drug Metabolism in Neonates" Congress of the European Society for Developmental, Perinatal and Pediatric Pharmacology, Oslo, Norway, June 2011 [Oral]

Leeder JS "Childhood Development and Adverse Drug Reactions" \European Society for Developmental, Perinatal and Pediatric Pharmacology, Oslo, Norway, June 2011 [Oral]

Leeder JS "Recent Advances in Cytochrome P450 Isoforms and Pharmacogenetic Polymorphisms" 13th Biennial Congress of the European Society for Developmental, Perinatal and Pediatric Pharmacology, Oslo, Norway, June 15, 2011, [Oral]

Leeder JS "Phenotyping Studies in Children: Why, How and Issues to be Addressed" Pediatric Ethics Subcommittee of the Pediatric Advisory Committee, Food and Drug Administration, Bethesda, MD, May 2011 [Oral]

Leeder JS "Pharmacogenomics and Implications for Drug Effects and Toxicity in Children" American College of Medical Toxicology (Teens, Tots, and Toxicology), Clearwater Beach, FL, March 2011 [Oral]

Leeder JS "Pharmacogenomics and Personalized Medicine: Why Should We Care?" National Pharmacy Forum, Phoenix, AZ, February 2011 [Oral]

Patel D, van Haandel L, Lasky A, Hoeltzel MF, Leeder JS, Becker ML "The Relationship of Folate and Methotrexate with Drug Response in Juvenile Idiopathic Arthritis" Plenary Session at Midwest Society for Pediatric Research, Madison, WI, October 2011 [Oral]

Poola A, van Haandel L, Gaedigk R, Talib N, Leeder JS, Becker ML "Intracellular Folate Concentration and Polyglutamate Distribution in Down Syndrome" Pediatric Academic Society, Denver, CO, May 2011 [Oral]

Saunders CJ "A Screen for Childhood Disease " Arbeitsgemeinschaft fur Gen-Diagnostik, Potsdam, Germany, October 2011 [Oral]

van Haandel L, Leeder JS, Becker ML "Measurement of Methotrexate Metabolites in Peripheral Blood Mononuclear Cells in Juvenile Idiopathic Arthritis: Hope for Individualization of Therapy? " ACR Nation Meeting, Chicago, IL, November 2011 [Poster]

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