Transplant research activities conducted at Children's Mercy are
designed to improve the overall transplant experience and outcome
for our patients.
- Evaluation of immunosuppressive dosing regimens as part of our
quality improvement activities has resulted in modification of
medication administration schedules and more prompt achievement of
therapeutic drug levels.
- We are working with colleagues in the Center for Personalized
Medicine and Therapeutic Innovation to explore the influence of
genomic-based variations in patient drug metabolism characteristics
on individualized treatment regimens.
- Our program is a regular participant in national
industry-sponsored pharmaceutical studies. Current protocols are
addressing the use of erythropoietic stimulating agents, vitamin D
and anti-viral agents in transplant recipients.
- We are one of a select group of pediatric transplant programs
in the country participating in a study sponsored by the National
Institutes of Health of antihypertensive therapy in pediatric
- The transplant, dialysis and general nephrology programs are
active members of the North American Pediatric Renal Trials and
Collaborative Studies (NAPRTCS). Activities include data entry into
the transplant, dialysis and chronic kidney disease registries,
participation in the benchmarking project, and frequent patient
entry into prospective clinical trials.