Children's Mercy Hospitals and Clinics is committed to providing patients the best medical care possible. This commitment goes hand in hand with our to dedication discovering and pioneering the latest treatment methods through innovative clinical research.

We are dedicated to advancing pediatric cancer research and participate in more than 80 clinical and laboratory cancer trials through the Children's Oncology Group and other national consortia. And our Phase I and II Experimental Therapeutics research leverages our unique strength in pediatric pharmacology to help make cancer medications safer and more effective for children. 

2011 Research Highlights

Peer-Reviewed Articles

August KJ, Dalton A, Katzenstein HM, George B, Olson TA, Wasilweski-Masker K, Rapkin LB.  The use of zoledronic acid in pediatric cancer patients. Pediatric Blood and Cancer 56: 610-614 (2011)

Changho SC, Hays JA , Saunders C, Rivard DC, Ahmed A. Pediatric Gastrointestinal Stromal Tumors in Assocation with Neuroblastoma.  APMIS 119 (2): 164-166 (2010

Fulbright JM, Raman S, McClellan WS, August KJ. Late effects of childhood leukemia therapy. Current Hematologic Malignancy Reports 6(3):195-205 (2011)

Gamis A, Alonzo T, Gerbing R, Hilden J, Sorrell A, Kumar M, Loew T, Arceci R, Barnard D, Doyle J, Massey G, Perentesis J, Ravindranath Y, Taub J, Smith F.  Natural history of transient myeloproliferative disorder (TMD) In down syndrome neonates: Outcomes from Children's Oncology Group (COG) study A2971.  Blood 118(26): 6752-6759 (2011)

Guest EM,Neville KA, Hoyer JD, Safo MK, Garg U, Saunders CJ, Abdulmalik O, Zwick DL. Hemoglobin Lake Tapawingo [α46 (CE4)Phe→Ser; HBA2:c.140T>C]: A new unstable α chain hemoglobin variant associated with low systemic arterial saturation. Hemoglobin 35(4): 411-416 (2011)

Hulbert ML, Woods G, et al. Silent cerebral infarcts occur despite regular blood transfusion therapy after first stroke in children with sickle cell disease. Blood 117(3): 772-779 (2011)

Kurth M, Puetz J, Kouides P, Sanders J, Sexauer C, Bernstein J, Gruppo R, Manco-Johnson M, Neufeld EJ, Rodriguez N, Wicklund B, Quon D, Aledort L. The use of a single von Willebrand factor-containing, plasma-derived FVIII product in hemophilia A immune tolerance induction: the US experience. J Thromb Haemost 9(11): 2229-2234 (2011)

Leissinger C, Gringeri A, Antmen B, Berntorp E, Biasoli C, Carpenter S, Cortesi P, Jo H, Kavakli K, Lassila R, Morfini M, Negrier C, Rocino A, Schramm W, Serban M, Uscatescu MV, Windyga J, Zulfikar B, Mantovani L.  Anti-inhibitor coagulant complex prophylaxis in hemophilia with inhibitors. The New England Journal of Medicine 365: 1684-1692 (2011)

Lewing K, Britton K , Debaun M, Woods G. The impact of parenteral narcotic choice in the development of acute chest syndrome in sickle cell disease. Journal of Pediatric Hematology Oncology 33(4): 255-260 (2011)

Louis CU, Savoldo B, Dotti G, Pule M, Yvon E, Myers GD, Rossig C, Russell HV, Diouf O, Liu E, Liu H, Wu MF, Gee AP, Mei Z, Rooney CM, Heslop HE, Brenner MK. Antitumoractivity and long-term fate of chimeric antigen receptor-positive Tcells in patients with neuroblastoma. Blood 118(23): 6050-6056 (2011)

Marcus N, Takada H, Law J, Cowan MJ, Gil J, Regueiro J, Plaza Lopez de Sabando D, Lopez-Granados E, Dalal J, Friedrich W, Manfred H, Celine Hanson I, Grunebaum E, Shearer WT, Roifman CM. Hematopoieticstem cell transplantation for CD3δ deficiency.  J Allergy Clin Immunol 128(5): 1050-1057 (2011)

Mathew P, Gerbing R, Alonzo T, Wallas T, Gong J, Jasty R, Jorstad D, Raimondi S,  Chavez C, Eisenberg N, Hirsch B, Gamis A, Smith F, Arceci R.  Phase II study of amifostine in children with myelodysplastic syndrome: A report  from the Children's Oncology Group.  Pediatr Blood Cancer 57(7): 1230-1232 (2011)

Wang WC, Kalpatthi R, et al. A multicenter phase III trial of hydroxyurea in young children with sickle cell anemia (BABY HUG). Lancet 377: 1663-1672 (2011) [supported by federal funding - NIH]

Scientific Presentations - Oral or Poster Format

Flatt, T,Neville, K,Dalal, J "KL-6 as a Marker for Bronchiolitis Obliterans in Pediatric and Young Adults Bone Marrow Transplant Patients"  ASBMT meeting, Honolulu, HW 2011 [Poster]

Villanueva MA , Mays LZ, Kalpatthi R, Woods G "Sickle-Hereditary Persistence of Fetal Hemoglobin- An Enigma?" Sickle Cell Disease Research and Educational Symposium & Annual National Sickle Cell Disease Scientific Meeting, Hollywood, FL, Feb 2011 [Poster]