Hematology Oncology and Bone Marrow Transplantation 2012 Research

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Hematology Oncology and Bone Marrow Transplantation 2012 Research

Peer-Reviewed Articles

Aplenc R, Fisher BT, Huang YS, Li Y, Alonzo TA, Gerbing RB, Gamis A. Merging of the National Cancer Institute–funded Cooperative Oncology Group Data with An Administrative Data Source to Develop a More Effective Platform for Clinical Trial Analysis and Comparative Effectiveness Research: A Report from the Children's Oncology Group. Pharmacoepidemiology and Drug Safety. 21(S2):37-43 (2012) 

Carpenter SL, Soucie M, Sterner S, Presley R. Increased Prevalence of Inhibitors in Hispanic Patients with Severe Haemophilia A Enrolled in the Universal Data Collection Database. Haemophilia 18(3):260-265 (2012)

Cooper TM, Franklin J, Gerbing RB, Alonzo TA, Hurwitz C, Raimondi SC, Gamis A. AAML03P1, A Pilot Study of the Safety of Gemtuzumab Ozogamicin in Combination with Chemotherapy for Newly Diagnosed Childhood Acute Myeloid Leukemia. Cancer 118(3):761-769 (2012)

Dalal J, Gandy K, Domen J. Role of Mesenchymal Stem Cell Therapy in Crohn’s Disease. Pediatric Research 71(4-2):445-451 (2012).

Domen J, Gandy K, Dalal J. Emerging Uses for Pediatric Hematopoietic Stem Cells. Pediatric Res 71(4-2):411-417(2012).

Flatt T, Neville K, Lewing K, Dalal J. Successful Treatment of Fanconi Anemia and T-Cell Acute Lymphoblastic Leukemia. Case Reports in Hematology (2012)

Gamis A, Smith O. Transient Myeloproliferative Disorder in Children with Down Syndrome: Clarity to this Enigmatic Disorder. British Journal of Haematology 122(3):277-287(2012)

Ginn KF, Gajjar A. Atypical Teratoid Rhabdoid Tumor: Current Therapy and Future irections. Frontiers in Oncology, 2(114)(2012)

Hay CR, DiMichele DM; International Immune Tolerance Study: Abshire TC, Allen G, Ayala I, Aznar JA, Barnard D, Bennett C, Carcao M, Cohen AJ, Collins P, Demers C, Dunn A, Escobar M, Ewing N, Feldman B, Flug F, Gill J, Glomstein A, Goudemand J, Guron G, Hanley J, Wicklund B, et al. The Principal Results of the International Immune Tolerance Study: A Randomized Dose Comparison. Blood 119(6):1335-1344 (2012)

Held K, Rahmetulla R, Loew TW, Radhi MA. Complete Resolution of Guttate Psoriasis Following Autologous SCT for Ewing’s Sarcoma in a Pediatric Patient. Bone Marrow Transplantation 47(12):1585-1586 (2012)

Iyamu EW, Perdew, HA, Woods GM. Oxidant-mediated Modification of the Cellular Thiols is Sufficient for Arginase Activation in Cultured Cells. Molecular and Cellular Biochemistry. 360(1);159-168 (2012) [supported by federal funding-NIH]

Jackson J, Carpenter S, Anderst J. Challenges in the Evaluation for Possible Abuse: Presentations of Congenital Bleeding Disorders in Childhood. Child Abuse & Neglect 36:127-134 (2012)

Javazon EH, Radhi M, Gangadharan B, Perry J, Archer DR. Hematopoietic Stem Cell Function in a Murine Model of Sickle Cell Disease. Anemia (2012)

Kelly M, Unguru Y, Myers GD, Lantos, J. Ethics Rounds: An 8-Year-Old Foster Child With Behavioral Problems Who Needs a Bone Marrow Transplant. Pediatrics 130(5)936-940 (2012)

Kutny MA, Moser BK, Laumann K, Feusner JH, Gamis A, Gregory J, Meshinchi S. FLT3 Mutation Status is a Predictor of Early Death in Pediatric Acute Promyelocytic Leukemia: A Report from the Children's Oncology Group. Pediatric Blood & Cancer 59(4):662-667(2012)

Loken M, Alonzo T, Pardo L, Gerbing R, Raimondi S, Hirsch B, Ho P, Franklin J, Cooper T, Gamis A, Meshinchi S. Residual Disease Detected by Multidimensional Flow Cytometry Signifies High Relapse Risk in Patients with De Novo Acute Myeloid Leukemia: A Report from Children's Oncology Group. Blood 120 (8): 1581-1588 (2012)

Luo Z, Lin C, Guest E, Garrett A, Mohaghegh N, Swanson S, Marshall A, Florens L, Washburn M, Shilatifard A. The Super Elongation Complex Family of RNA Polymerase II Elongation Factors: Gene Target Specificity and Transcriptional Output. Molecular and Cellular Biology 32(13): 2608-2617(2012).

Miller CH, Benson J, Ellingsen D, Driggers J, Payne A, Kelly FM, Wicklund BM, et al; Hemophilia Inhibitor Research Study Investigators. F8 and F9 Mutations in US Haemophilia Patients: Correlation with History of Inhibitor and Race/Ethnicity. Haemophilia 18(3):375-82 (2012).

Miller CH, Platt SJ, Rice AS, Kelly F, Wicklund BM, et al; Hemophilia Inhibitor Research Study Investigators.Validation of Nijmegen-Bethesda Assay Modifications to Allow Inhibitor Measurement During Replacement Therapy and Facilitate Inhibitor Surveillance. J Thromb Haemost 10(6):1055-1061 (2012)

Pollard JA, Alonzo TA, Loken M, Gerbing RB, Ho PA, Bernstein ID, Raimondi SC, Hirsch B, Franklin J, Walter RB, Gamis A, Meshinchi S. Correlation of CD33 expression level with disease characteristics and response to gemtuzumab ozogamicin containing chemotherapy in childhood AML. Blood 119(16), 3705-3711 (2012)

Powell J, Martinowitz U, Windyga J, Di Minno G, Wicklund BM, et al; LipLong Study Investigators. Efficacy and Safety of Prophylaxis with Once-weekly BAY 79-4980 Compared with Thrice-weekly rFVIII-FS in Haemophilia A Patients; A Randomized, Active-controlled, Double-blind Study. Thromb Haemost 108(5):913-922, (2012)

Radhi M, Carpenter S. Thrombotic Microangiopathies. ISRN Hematology (2012)

Shapiro AD, Tarantino M, Wicklund BM, Manco-Johnson MJ, Dunn AL, Knoll C, Barrett JC, Radhi M, Lentz SR, Kempton CL, Kelley F, et al.; Hemophilia Inhibitor Research Study Investigators. Validation of Nijmegen-Bethesda Assay Modifications to Allow Inhibitor Measurement During Replacement Therapy and Facilitate Inhibitor Surveillance. J Thromb Haemost 10(6):1055-1061 (2012)

Sorrell AD, Alonzo TA, Hilden JM, Gerbing RB, Loew TW, Hathaway L, Barnard D, Taub JW, Ravindranath Y, Smith FO, Arceci RJ, Woods WG, Gamis AS. Favorable Survival Maintained in Children Who Have Myeloid Leukemia Associated with Down Syndrome Using Reduced-dose Chemotherapy on Children's Oncology Group Trial A2971. Cancer 118: 4806–4814 (2012)

Sung L, Aplenc R, Alonzo T, Gerbing R, Burden L, Raimondi S, Hirsch B, Wallas T, Meshinchi S, Hall M, Bertoch D, Huang Y, Li Y, Fisher B, Gamis A. Predictors and short-term outcomes of hyperleukocytosis in children with acute myeloid leukemia: a report from the Children's Oncology Group. Haematologica 97(11):1770-1773 (2012)

Sung L, Buxton A, Gamis A, Woods WG, Alonzo TA. Life-threatening and Fatal Infections in Children With Acute Myeloid Leukemia: A Report From the Children’s Oncology Group. J Pediatr Hematology/Oncology 34(1): e30 (2012)

Teusink AC, Ragucci D, Shatat IF, Kalpatthi R. Potentiation of Vincristine Toxicity with Concomitant Fluconazole Prophylaxis in Children with Acute Lymphoblastic Leukemia. J Pediatr Hematology/Oncology 29(1): 62-67 (2012)

Thornburg CD, Carpenter S, Zappa S, Munn J, Leissinger C. Current Prescription of Prophylactic Factor Infusions and Perceived Adherence for Children and Adolescents with Haemophilia: A Survey of Haemophilia Healthcare Professionals in the United States. Haemophilia 18:568-574(2012)

Thornburg CD, Files BA, Luo Z, Miller ST, Kalpatthi R, Iyer R. Impact of Hydroxyurea on Clinical Events in the BABY HUG Trial. Blood 120:4304-4310 (2012)

Wen Q, Goldenson B, Silver S, Gamis A, et al.Identification of Regulators of Polyploidization Presents Therapeutic Targets for Treatment of AMKL. Cell 150(3): 575-589. (2012)

Wicklund B, et al.; LipLong Study Investigators. Efficacy and Safety of Prophylaxis with Once-weekly BAY 79-4980 Compared with Thrice-weekly rFVIII-FS in Haemophilia A Patients; A Randomized, Active-controlled, Double-blind Study. Throm Haemost 108(5): 913-922 (2012)

Scientific Presentations – Oral or Poster Format

August KJ “A Phase I Study of AC220 in Combination with Cytarabine and Etoposide in Relapsed/Refractory Childhood ALL and AML: A Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Study 2012” American Society of Hematology Meeting, Atlanta GA, December 2012 [Poster]

Bolouri H, Ries RE, Ramamurthy R, Alonzo TA, Guidry-Auvil JM, Davidsen TM, Gesuwan P, Gamis AS, Smith MA, Gerhard DS, Arceci RJ, Meshinchi S. “Integrative Network Analysis of Pediatric AML Whole Genomes, cDNA Expression and Clinical Data Elements Reveals Shared As Well As t(8;21), Inv16 and MLL Specific Pathways; A Report From COG/NCI Target AML Initiative” American Society of Hematology Annual Meeting, Atlanta GA, December 2012 [Poster]

Carpenter SL, Goldman J, Sherman A, Bell JJ, Selvaraju S, Selvarangan R “Staphylococcus Aureus Virulence Factors Surface Associated Adhesion (sdrD) and Fibronectin-binding Protein B (fnbB) Associated with Deep Vein Thrombosis in Pediatric Patients” Thrombosis and Hemostasis Summit of North America, Chicago IL, 2012 [Oral]

Cooper T, Alonzo TA, Gerbing RB, Perentesis J, Whitlock JA, Taub JW, Horton TM, Gamis AS, Razzouk BI “AAML0523: A Report From the Children's Oncology Group On the Efficacy of Clofarabine in Combination with Cytarabine in Pediatric Patients with Relapsed Acute Myeloid Leukemia” American Society of Hematology Annual Meeting, Atlanta GA, December 2012 [Poster]

Dalal J, Ashraf H, Yankee T, McGuirk J, Abhyankar S "An Immunological Assessment of B and T Cells in Patients with Chronic Graft Vs Host Disease Undergoing Extracorporal Photopheresis (ECP)" ASBMT Tandem Meeting, San Diego CA, February 2012 [Poster]

Elliott A, Toy S, Carpenter SL, Lantos J, Stegenga K, Hilden J “Palliative Care Education: Preliminary Results of a Survey of Pediatric Oncologists” American Society of Pediatric Hematology Oncology, New Orleans LA, May 2012 [Poster]

Flatt T, Hays A, Woods G. “Building a New Model of Clinical Care: Hospitalist Coverage on the Hematology/Oncology In-patient Service” American Society of Pediatric Hematology Oncology, New Orleans, LA May 2012 [Poster]

Goldman J, Carpenter SL, Sherman A, Bell JJ, Selvarangan R “Bacterial Virulence Factors Associated with Deep Vein Thrombosis in Pediatric Patients with Staphylococcus Aureus Infections” Pediatric Academic Societies Meeting, Boston MA, April 2012 [Oral]

Helton HL, Ries RE, Alonzo TA, Gerbing RB, Trevino LR, Farrar J, Guidry-Auvil JM, Davidsen TM, Gesuwan P, Muzny DM, Gamis AS, Franklin J, Wheeler DA, Smith MA, Gerhard DS, Arceci RJ, Meshinchi S “Clinically Significant Mutations, Deletions and Translocations Involving ETV6 Identified by Whole Genome and Whole Exome Sequencing: Report From NCI/COG Target AML Initialtive” American Society of Hematology Annual Meeting, Atlanta GA, December 2012 [Oral]

Ho PA, Alonzo TA, Gerbing RB, Sung L, Aplenc R, Pollard JA, Kuhn J, Heerema NA, Lange BJ, Gamis AS, Meshinchi S “WT1 snp rs16754 Genotype Predicts Treatment Related Mortality (TRM) in African-American and Asian Pediatric AML Patients: A Report From the Children's Oncology Group” American Society of Hematology Annual Meeting, Atlanta GA, December 2012 [Poster]

Ho PA, Alonzo T, Gerbing RB, Pollard JA, Raimondi SC, Hirsch BA, Cooper T, Gamis AS, Meshinchi S “High EVI1 Expression is Associated with MLL Rearrangements and Predicts Decreased Survival in Pediatric AML: A Report From the Children's Oncology Group” American Society of Hematology Annual Meeting, Atlanta GA, December 2012 [Poster]

Horton TM, Perentesis J, Gamis AS, Alonzo TA, Gerbing RB, Ballard J, Adlard K, Howard D, Smith FO, Moscow JA “A Phase 2 Study of Bortezomib Combined with Reinduction Chemotherapy in Children and Young Adults with Recurrent, Refractory or Secondary Acute Myeloid Leukemia: A Childen's Oncology Group (COG) Study” American Society of Hematology Annual Meeting, Atlanta GA, December 2012 [Poster]

Jones G, Kalpatthi R, Woods G “Practice Patterns of Stroke Screening and Hydroxyurea Use in Children with Sickle Cell Disease: A Survey of Health Care Providers” American Society of Pediatric Hematology Oncology, New Orleans LA, May 2012 [Poster]

Kalpatthi R, Lee BR, Dalal J “Hospitalization Trend for Children and Adolescents with Sickle Cell Disease in the USA: A Pediatric Health Information Database Analysis” American Society of Hematology Annual Meeting, Atlanta GA, December 2012 [Oral]

Klemp J, Stegenga K, Nelson E, McClel W, Ryan R, Krebill H, Panicker J, Sharma, M “Adult Survivors of Childhood Cancers: Survey Results of Long-Term Survivorship Issues and Implications for Regional Program Development” 6th Biennial Cancer Surviorship Research Conference, Arlington VA, June 2012 [Poster]

Kutny MA, Alonzo TA, Gerbing RB, Franklin J, Raimondi SC, Hirsch BA, Gamis AS, Meshinchi S “Expression of RUNX1 and RUNX1T1 Correlates with Cytogenetic Subgroups in Pediatric AML: A Report From the Children's Oncology Group” American Society of Hematology Annual Meeting, Atlanta GA, December 2012 [Poster]

Lederman HM, Connolly MA, Kalpatthi R, Ware RE, Wang WC, Luchtman-Jones L, Waclawiw M, Goldsmith JC, Casella JF “Effects of Hydroxyurea (HU) On Lymphocyte Subsets and the Immune Response to Pneumococcal, Measles, Mumps, and Rubella Vaccination in the Pediatric Hydroxyurea Phase III Clinical Trial - BABY HUG - (ClinicalTrails.gov Identifier: NCT00006400)” American Society of Hematology Annual Meeting, Atlanta GA, December 2012 [Oral]

Leonard S, Harris J, Warner T, Fuh B, Grossi M, Daeschner C, and Jefferson MR “Attitudes and Practices of Providers Regarding School Reintegration for Children with Acture Lymphoblastic Leukemia” American Society of Pediatric Hematology Oncology, New Orleans LA, May 2012 [Poster]

Meshinchi S, Ries RE, Trevino LR, Hampton OA, Alonzo T, Farrar JE, Guidry-Auvil JM, Davidsen TM, Gesuwan P, Muzny DM, Gamis AS, Helton HL, Wheeler DA, Smith MA, Gerhard DS, Arceci RJ “Identification of Novel Somatic Mutations, Regions of Recurrent Loss of Heterozygosity (LOH) and Significant Clonal Evolution from Diagnosis to Relapse in Childhood AML Determined by Exome Capture Sequencing - An NCI/COG Target AML Study” American Society of Hematology Annual Meeting, Atlanta GA, December 2012 [Oral]

Meshinchi S, Ries R, Farrar J, Auvil J, Davidsen T, Gesuwan P, Trevino L, Muzny D, Wheeler D, Gamis A, Alonzo T, Smith M, Gerhard D, Arceci R “Demonstration of Significant Clonal Evolution from Diagnosis to Relapse in Childhood AML Determined by Exome Capture Sequencing - An NCI/COG TARGET AML Study” American Association of Cancer Research, Chicago IL, March 2012 [Poster]

Ochs M, Farrar J, Considine M, Ries RE, Trevino LR, Alonzo TA, Guidry-Auvil J, Davidsen TM, Gesuwan P, Muzny DM, Gamis AS, Wheeler DA, Helton HL, Smith MA, Gerhard DS, Meshinchi S, Arceci RJ “Genome Wide Promoter Methylation Patterns Predict AML Subtype Outcomes and Identify Novel Pathways Characeterizing Diagnostic and Relapsed Disease in Children” American Society of Hematology Annual Meeting, Atlanta GA, December 2012 [Poster]

Ostronoff F, Fitzgibbon M, McIntosh M, Ries RE, Gamis AS, Alonzo TA, Appelbaum FR, Stirewalt DL, Meshinchi S “RNA-Sequencing Unveils Cryptic Fusions in Patients with Acute Myeloid Leukemia” American Society of Hematology Annual Meeting, Atlanta GA, December 2012 [Poster]

Ostronoff F, Alonzo TA, Gerbing RB, Loken MR, Pardo L, Aplenc R, Sung L, Raimondi SC, Hirsch BA, Kahwash S, Heerema-McKenny A, Winter L, Glick K, Byron P, Lavey RS, Davies SM, Smith FO, Gamis AS, Meshinchi S “Cryptic NUP98/NSD1 Translocations Are Highly Prevalent in FLT3/ITD-Positive Acute Myeloid Leukemia and Lead to High Rate of Induction Failure: A Report From Children's Oncology Group” American Society of Hematology Annual Meeting, Atlanta GA, December 2012 [Oral]

Palomo-Moraleda P, Alonzo TA, Gerbing RB, Raimondi SC, Hirsch BA, Ravindranath Y, Lange B, Woods WG, Gamis AS, Meshinchi S “Acute Myeloid Leukemia with t(6;9)(p23;q34) is Associated Poor Outcome in Childhood AML Regardless of FLT3/ITD Status: A Report From Children's Oncology Group” American Society of Hematology Annual Meeting, Atlanta GA, December 2012 [Poster]

Paroskie A, Carpenter S, Lowen D, Anderst J, DeBaun MR, Sidonio RF “Retrospective Review of Hematologic Evaluation in Children with Suspected Non-accidental Injury: A First Step Towards Evidence Based Guidelines” American Society of Hematology Annual Meeting, Atlanta GA, December 2012 [Poster]

Pollard JA, Alonzo TA, Gerbing RB, Ho PA, Raimondi SC, Hirsch BA, Franklin J, Gamis AS, Meshinchi S “Elevated BAALC Gene Expression Lacks Clinical Significance in Pediatric AML: A Report From the Children's Oncology Group.” American Society of Hematology Annual Meeting, Atlanta GA, December 2012 [Poster]

Ramamurthy R, Alonzo TA, Gerbing RB, Loken MR, Pardo L, Aplenc R, Sung L, Raimondi SC, Hirsch BA, Kahwash S, Heerema-McKenney A, Winter L, Glick K, Byron P, Francisco LE, Lavey RS, Davies SM, Smith FO, Gamis AS, Meshinchi S “Elevated Expression of miR-181a and miR-155 Identify Pediatric AML Patients at High Risk of Induction Failure: A Report from Children's Oncology Group” American Society of Hematology Annual Meeting, Atlanta GA, December 2012 [Poster]

Routhieaux J, Sarcone S, Woods G, Kalpatthi R “Utility of Electronic Critical Information Note in the Management of Children with Sickle Cell Disease” 6th Annual Sickle Cell Disease Scientific Meeting, Hollywood FL, March 2012 [Poster]

Sarcone S, Routhieaux J, Seal A, Mehrhof A, Woelk A, Kalpatthi R, Woods G “Camp Courage: Campers and Caregivers Perspectives” 6th Annual Sickle Cell Disease Scientific Meeting, Hollywood, FL, March 2012 [Poster]

Silvey M, Carpenter S, Wicklund B “The Development of Pulmonary Embolus in Two Patients with Hemophilia A and High Titer Inhibitors” Thrombosis and Hemostasis Symposium of North America, Chicago IL, May 2012 [Poster]

Sorrell A, Taub J, Alonzo T, Gerbing R, Meshinchi S, Berman J, Hilden J, Gamis A “Remission Marrow Blast Percentage Predicts Relapse Risk in Children With Myeloid Leukemia Associated with Down Syndrome” American Society of Pediatric Hematology Oncology, New Orleans LA, May 2012 [Poster]

Stirewalt DL, Alonzo TA, Pogosova-Agadjanyan EL, Gerbing RB, Franklin J, Lee H, Raimondi SC, Hirsch BA, Gamis AS, Meshinchi S. “Novel IRF8 Splice Variants are Validated as a New Prognostic Biomarker for Adverse Outcome in an Independent Population of Pediatric Patients with AML” American Society of Hematology Annual Meeting, Atlanta GA, December 2012 [Poster].

Stirewalt DL, Alonzo TA, Pogosova-Agadjanyan EL, Gerbing RB, Franklin J, Raimondi SC, Hirsch BA, Gamis AS, Meshinchi S. “Novel IL23R Splice Variant Is Associated with Worse Prognosis in Pediatric Patients with AML” American Society of Hematology Annual Meeting, Atlanta GA, December 2012 [Poster]

Sung L, Aplenc R, Alonzo TA, Gerbing RB, Lehrnbecher T, Gamis AS “Effectiveness of Supportive Care Measurements to Reduce Infections During Induction for Children with Acute Myeloid Leukemia: A Report from the Chidren's Oncology Group” American Society of Hematology Annual Meeting, Atlanta, GA December 2012 [Poster]

Thornton KM, Nyp MF, Music-Aplenc L, Jones GL, Carpenter SL, Guest EM, Manimtim WM “A Rare Case of Bilirubin Encephalopathy in a One-Day-Old Infant” Pediatric Academic Societies Meeting, Boston MA, April 2012 [Poster]

Tran J, Pacicca D, Woods G, Kalpatthi R “X-ray Screening and Avascular Necrosis of Femoral Head in Children and Adolescents with Sickle Cell Disease” The American Society of Pediatric Hematology Oncology, Baltimore MD, April 2012 [Poster]

Villanueva MA, Saunders CJ, Zwick D, Smith L, Dinwiddie D, Farrow E, Miller NA, Kingsmore SF, August K “An Unusual Presentation of Congenital Dyserythropoietic Anemia Type II (CDAII) Associated with Severe Anemia in a Patient with a Novel Mutation of the SEC23B Gene” American Society of Hematology Annual Meeting, Atlanta GA, December 2012 [Poster]

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