Hematology Oncology and Bone Marrow Transplantation 2011 Research

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Hematology Oncology and Bone Marrow Transplantation 2011 Research

Peer-Reviewed Articles

August KJ, Chiang KY, Bostick RM, Flanders WD, Waller EK, Langston A, Worthington-White D, Rowland P, Moore KF, Khoury HJ, Horan JT. Biomarkers of immune activation to screen for severe, acute GVHD. Bone Marrow Transplantation 46(4): 601-604 (2011)

August KJ, Dalton A, Katzenstein HM, George B, Olson TA, Wasilweski-Masker K, Rapkin LB.  The use of zoledronic acid in pediatric cancer patients. Pediatric Blood and Cancer 56: 610-614 (2011)

Berman J, Gerbing R, Alonzo T, Ho P, Miller K, Hurwitz C, Heerema N, Hirsch B, Raimondi S, Lange B, Franklin J, Gamis A, Meshinchi S. Prevalence and clinical implications of NRAS mutations in childhood AML: A report from the Children’s Oncology Group. Leukemia 25(6): 1039-1042 (2011)

Bishop S, Matheus MG, Abboud MR, Cane ID, Adams RJ, Jackson SM, Kalpatthi R. Effect of chronic transfusion therapy on progression of neurovascular pathology in pediatric patients with sickle cell anemia. Blood Cells Mol Dis 47(2): 125-128 (2011)

Changho SC, Niece JA , Saunders C, Rivard DC, Ahmed A. Pediatric Gastrointestinal Stromal Tumors in Assocation with Neuroblastoma APMIS 119 (2): 164-166 (2011)

Fulbright JM. Review of cardiotoxicity in pediatric cancer patients: During and after therapy. Cardiol Res Pract 2011: 942090 (2011)

Fulbright JM, Raman S, McClellan WS, August KJ. Late effects of childhood leukemia therapy. Current Hematologic Malignancy Reports 6(3):195-205 (2011)

Gamis A, Alonzo T, Gerbing R, Hilden J, Sorrell A, Kumar M, Loew T, Arceci R, Barnard D, Doyle J, Massey G, Perentesis J, Ravindranath Y, Taub J, Smith F.  Natural history of transient myeloproliferative disorder (TMD) In down syndrome neonates: Outcomes from Children's Oncology Group (COG) study A2971.  Blood 118(26): 6752-6759 (2011)

Guest EM, Neville KA, Hoyer JD, Safo MK, Garg U, Saunders CJ, Abdulmalik O, Zwick DL. Hemoglobin Lake Tapawingo [α46 (CE4)Phe→Ser; HBA2:c.140T>C]: A new unstable α chain hemoglobin variant associated with low systemic arterial saturation. Hemoglobin 35(4): 411-416 (2011)

Ho P, Alonzo T, Gerbing R, Kutny M, Joaquin J, Raimondi S, Hirsh B, Gamis A, Meshinchi S. Leukemic mutations in the methylation-associated genes DNMT3A and IDH2 are rare events in pediatric AML: A report from the Children’s Oncology Group. Pediatr Blood Cancer 57(2): 204-209 (2011)

Ho P, Kopecky K, Alonzo T, Gerbing R, Miller K, Kuhn J, Zeng R, Ries R, Raimondi S, Hirsch B, Oehler V, Hurwitz C, Franklin J, Gamis A, Petersdorf S, Anderson J, Godwin J, Reaman G, Willman C, Bernstein I, Radich J, Appelbaum F, Stirewalt D, Meshinchi S. Prognostic implications of the IDH1 synonymous SNP rs11554137 in pediatric and adult AML: A report from the Children’s Oncology Group and SWOG. Blood 118(17): 4561-4566 (2011)

Ho P, Kuhn J, Gerbing R, Pollard J, Zeng R, Miller K, Heerema N, Raimondi S, Hirsch B, Franklin J, Lange B, Gamis A, Alonzo T, Meshinchi S. The WT1 synonymous SNP rs16754 correlates with higher mRNA expression and predicts significantly improved outcome in favorable-risk pediatric AML: A report from the Children’s Oncology Group. Journal of Clinical Oncology 29(6): 704-711 (2011)

Hulbert ML, Woods G, et al. Silent cerebral infarcts occur despite regular blood transfusion therapy after first stroke in children with sickle cell disease. Blood 117(3): 772-779 (2011)

Kauffman J. Recombinant infusion therapies indicated for the treatment of bleeding disorders. Journal of the Infusion Nursing Society 34(1): 29-35 (2011)

Kurth M, Puetz J, Kouides P, Sanders J, Sexauer C, Bernstein J, Gruppo R, Manco-Johnson M, Neufeld EJ, Rodriguez N, Wicklund B, Quon D, Aledort L. The use of a single von Willebrand factor-containing, plasma-derived FVIII product in hemophilia A immune tolerance induction: the US experience. J Thromb Haemost 9(11): 2229-2234 (2011)

Leissinger C, Gringeri A, Antmen B, Berntorp E, Biasoli C, Carpenter S, Cortesi P, Jo H, Kavakli K, Lassila R, Morfini M, Negrier C, Rocino A, Schramm W, Serban M, Uscatescu MV, Windyga J, Zulfikar B, Mantovani L.  Anti-inhibitor coagulant complex prophylaxis in hemophilia with inhibitors. The New England Journal of Medicine 365: 1684-1692 (2011)

Lewing K, Britton K, Debaun M, Woods G. The impact of parenteral narcotic choice in the development of acute chest syndrome in sickle cell disease. Journal of Pediatric Hematology Oncology 33(4): 255-260 (2011)

Louis CU, Savoldo B, Dotti G, Pule M, Yvon E, Myers GD, Rossig C, Russell HV, Diouf O, Liu E, Liu H, Wu MF, Gee AP, Mei Z, Rooney CM, Heslop HE, Brenner MK. Antitumoractivity and long-term fate of chimeric antigen receptor-positive Tcells in patients with neuroblastoma. Blood 118(23): 6050-6056 (2011)

Marcus N, Takada H, Law J, Cowan MJ, Gil J, Regueiro J, Plaza Lopez de Sabando D, Lopez-Granados E, Dalal J, Friedrich W, Manfred H, Celine Hanson I, Grunebaum E, Shearer WT, Roifman CM. Hematopoieticstem cell transplantation for CD3δ deficiency.  J Allergy Clin Immunol 128(5): 1050-1057 (2011)

Mathew P, Gerbing R, Alonzo T, Wallas T, Gong J, Jasty R, Jorstad D, Raimondi S,  Chavez C, Eisenberg N, Hirsch B, Gamis A, Smith F, Arceci R.  Phase II study of amifostine in children with myelodysplastic syndrome: A report  from the Children's Oncology Group.  Pediatr Blood Cancer 57(7): 1230-1232 (2011)

McCarville MB, Kalpatthi R, et al. Abdominal ultrasound findings in infants with sickle cell anemia: Baseline data from the BABY HUG trial. Am J Roentgenol 196: 1399-1404 (2011) [supported by federal funding – NIH]

Soucie JM, Wang C, Siddiqi A, Kulkarni R, Recht M, Konkle BA; Hemophilia Treatment Center Network. The longitudinal effect of body adiposity on joint mobility in young males with Haemophilia A. Haemophilia 17(2): 196-203 (2011)

Wang WC, Kalpatthi R, et al. A multicenter phase III trial of hydroxyurea in young children with sickle cell anemia (BABY HUG). Lancet 377: 1663-1672 (2011) [supported by federal funding - NIH]

Scientific Presentations - Oral or Poster Format

Aplenc R, Fisher B, Sung L, Keren R, Alonzo T, Hall M, Huang Y, Li Y, Luan, X, Gerbing R, Bertoch D, Seif A, Adamson P, Gamis A. “Merging of Children’s Oncology Group and Pediatric Health Information Systems Data Source to Determine Resource Utilization and Treatment Costs on AAML0531: A Report from the Children’s Oncology Group” American Society of Hematology, San Diego, CA, December 2011 [Poster]

Bratcher B, Held K, Dalal J, Liewer S “Characterization of Busulfan Dose in Hematopoietic Stem Cell Transplant Patients Less Than 12 Months of Age” American Society of Bone marrow Transplantation Tandem Meetings, Honolulu, HI, February 2011 [Oral]

Canner J, Alonzo T, Franklin J, Freyer D, Gamis A, Gerbing R, Lange B, Meshinchi S, Woods W, Perentesis J, Horan J “Treatment Outcomes in Older Adolescent and Young Adult (AYA) Patients with Newly Diagnosed AML” American Society of Clinical Oncology, Chicago, IL, May 2011 [Oral]

Chisholm K, Kahwash S, Hirsch B, Raimondi S, Alonzo T, Gerbing R, Aplenc R, Sung L, Winter L, Glick K, Byron P, Burden L, Wallas T, Davies S, Smith F, Meshinchi S, Gamis A, Heerema-McKenney A “Acute Megakaryoblastic Leukemia (AMkL): The COG AML0531 Experience” Society for Pediatric Pathology Spring Meeting, San Antonio, TX, February 2011 [Poster]

Elliott, A, Flatt, T, Shore, R “Isolated de novo CNS AML in a 3 year old Child: Case Report” American Society of Pediatric Hematologists and Oncologists, Baltimore, MD 2011 [Poster]

Flatt, T, Neville, K, Dalal, J "KL-6 as a Marker for Bronchiolitis Obliterans in Pediatric and Young Adults Bone Marrow Transplant Patients"  ASBMT meeting, Honolulu, HW 2011 [Poster]

Held K, Smith S, Shreve N, Dalal J, Liewer S “Survey Results of Immunization Practices Following Hematopoietic Stem Cell Transplant Among Centers in the United States” American Society for Blood and Marrow Transplant Annual Meeting, Honolulu, HI, February 2011 [Poster]

Hills H, Held K, Klockau C, Deverill C, Radhi M “Relationship Between Tacrolimus Blood Concentrations and Incidence of Acute Graft-Versus-Host Disease During the First 28 and 100 Days After Hematopoietic Stem Cell Transplant in Children” Hematology Oncology Pharmacists Association Annual Meeting, Salt Lake City, UT, March 2011 [Poster]

Ho P, Alonzo T, Gerbing R, Kuhn J, Pollard J, Hirsch B, Raimondi S, Gamis A, Meshinchi S ”The Prognostic Effect of High WT1 Gene Expression in Pediatric AML Depends on WT1 SNP rs16754 Status: a Report from the Children’s Oncology Group (COG)” American Society of Hematology, San Diego, CA, December 2011 [Poster]

Kalpatthi R, Luo Z, Adams RJ, Brown RC, Casella JF, Pavlakis S, Iyer R, Thornburg CD, Miller ST, Wang WC, for the BABY HUG Investigators “Comparison of Hematologic Measurements between Local and Central Laboratories: Data from BABY HUG” American Society of Pediatric Hematology Oncology, Baltimore, MD, April 2011 [Poster]

Kalpatthi R, Zhibao M, Lu M, Thompson B, Wang WC, Patel N, Kutlar A, Howard, T, Luchtman-Jones L, Miller ST, for the BABY HUG Investigators “Effects of Hydroxyurea (HU) on Cerebral Blood Flow in Sickle Cell Anemia (SCA): Results from the BABY HUG Trial” American Society of Pediatric Hematology Oncology, Baltimore, MD, April 2011 [Poster]

Kutny M, Alonzo T, Gerbing R, Geraghty D, Gamis A, Lange B, Heerema N, Franklin J, Raimondi S, Hirsch B, Meshinchi S “TET2 Mutations Are Associated with Poor Outcome in Pediatric AML: A Report From the Children's Oncology Group” American Society of Hematology, San Diego, CA, December 2011 [Oral]

Lacayo N, Alonzo T, Gayko U, Westfall M, Purvis N, Putta S, Hackett J, Cohen A, Gerbing R, Dahl G, Gamis A, Meshinchi S “Single-Cell Network Profiling (SCNP)-based Classifier to Predict Response to Induction Therapy in Pediatric Patients with de novo Acute Myeloid Leukemia (AML): Validation Study Results” American Society of Hematology, San Diego, CA, December 2011 [Poster]

Loken M, Alonzo T, Pardo L, Gerbing R, Gamis A, Raimondi S, Hirsch B, Kahwash S, Heerema-McKinney A, Aplenc R, Sung L, Winter L, Glick K, Davies S, Byron P, Lavey R, Francisco L, Wallas T, Smith F, Meshinchi S “Presence of Residual Disease Identified by Multidimensional Flow Cytometry Identifies Patients with AML at High Risk of Relapse – a report from the Children’s Oncology Group” American Society of Hematology, San Diego, CA, December 2011 [Poster]

Loken M, Alonzo T, Pardo L, Gerbing R, Aplenc R, Sung L, Raimondi S, Hirsch B, Kahwash S, Heerema-McKinney A, Winter L, Glick K, Byron P, Lavey R, Francisco L, Wallas T, Davies S, Smith F, Gamis A, Meshinchi S “Multidimensional Flow Cytometry Significantly Improves upon the Morphologic Assessment of Post-Induction Marrow Remission Status – Comparison of Morphology and Multidimensional Flow Cytometry – A Report from the Children’s Oncology Group AML Protocol AAML0531” American Society of Hematology, San Diego, CA, December 2011 [Oral]

Miller K, Silvey M, Logsdon D, Balch F, Nsumu N, Sokolovsky, Gibson S, Bi C, Heruth D, PhD, White R “The Xla (X-linked anemia) Mouse: A Transient Neonatal Anemia Caused by a Gata1 Splicing Mutation” American Society of Hematology Annual meeting, San Diego, CA, December 2011 [Poster]

Moore A, Alonzo T, Gerbing R, Lange B, Heerema N, Franklin J, Raimondi S, Hirsch B, Gamis A, Meshinchi S “The Ratio of Alternate BIRC5 (Survivin) Splice Variants Correlates with Refractory Disease and Poor Outcome in Children with Acute myeloid Leukaemia: A Report from the Children’s Oncology Group” American Society of Hematology, San Diego, CA, December 2011 [Poster]

Ngwube A, Hlavacek A, Bowman M, Jackson SM, Kalpatthi R “Low Prevalence of Pulmonary Artery Hypertension in Children with Sickle Cell anemia” American Society of Pediatric Hematology Oncology, Baltimore, MD, April 2011 [Poster]

Nugent D, Bussel JB, Buchanan GR, Stine K, Kalpatthi R, Nie K, Eisen M “Long-term use of the Thrombopoietin-Mimetic Peptibody Romiplostim in Children with Chronic/Refractory Immune Thrombocytopenia (ITP): Results of an Open-label Extension Study” American Society of Pediatric Hematology Oncology, Baltimore, MD, April 2011 [Poster]

Thornburg C, Carpenter SL, Munn J, Zappa S, Leissenger CA “Prescription of Prophylaxis for Children with Hemophilia” American Society of Pediatric Hematology/Oncology Annual Meeting, Baltimore, MD April 2011 [POSTER]

Thornburg CD, Files B, Miller ST, Kalpatthi R, Iyer R, Seaman P, Ware RE, Luo Z, Wang WC, for the BABY HUG Investigators “Effects of Hydroxyurea on Pain, Dactylitis, Acute Chest Syndrome and Hospitalization in Sickle Cell Anemia (SCA): Results from The BABY HUG Trial” American Society of Pediatric Hematology Oncology, Baltimore, MD, April 2011 [Oral]

Thornburg CD, Files B, Miller ST, Kalpatthi R, Iyer R, Seaman P, Ware RE, Luo Z, Wang WC, for the BABY HUG Investigators “Febrile Episodes and Infections in Young Children with Sickle Cell Anemia (SCA): Data from the BABY HUG Trial” American Society of Pediatric Hematology Oncology, Baltimore, MD, April 2011 [Poster]

Villanueva MA, Mays LZ, Kalpatthi R, Woods G "Sickle-Hereditary Persistence of Fetal Hemoglobin- An Enigma?" Sickle Cell Disease Research and Educational Symposium & Annual National Sickle Cell Disease Scientific Meeting, Hollywood, FL, Feb 2011 [Poster]

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