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Atherosclerosis: A process that involves thickening of the blood vessel walls thought to be related to inflammation of the vessel wall, which then leads to formation of plaques, causing partial blockages. If these plaques rupture, clots form on that rupture site, causing a more acute, total blockage. If the blood vessel is providing blood to the heart, the result would be a heart attack.

Autoimmune Disease: Disorder of the body's immune system in which the immune system mistakenly attacks and destroys body tissue considered foreign such as in thyroid, diabetes, and celiac diseases.

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Basal Insulin: The insulin that controls blood glucose levels between meals and overnight.

Beta Cells: Cells in the pancreas that produce insulin.

Blood Glucose (or glucose): A type of sugar that is created when the carbohydrate that one eats is broken down in the body. During digestion, glucose passes through the wall of the intestine into the bloodstream to the liver and eventually into the general circulation. From there, glucose can then enter individual cells or tissues throughout the body to be used for fuel and provide energy.

Body Mass Index (BMI): A method of determining by the relationship between height and weight whether or not a person is obese, overweight, underweight, or of normal weight.

Bolus Insulin: Insulin that is released when food is eaten. A bolus is a burst of insulin that is delivered by injection or by the insulin pump to cover the carbohydrates in a meal or snack or to correct for a high blood glucose level.

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Carbohydrate: The main source of fuel for the body. Carbohydrate includes starches and sugars and are found in bread, pasta, fruits, vegetables, milk, and sweets. Carbs are broken down into a sugar called glucose.

Carbohydrate Counting: A meal planning method commonly used by people with diabetes to plan their food and meal choices. Carbohydrate counting helps one achieve a balance between the amount of carbohydrate foods eaten and the available insulin.

Cholesterol: A type of fat that is manufactured in the liver or intestines, but is also found in some of the foods we eat. (Only animal foods, such as eggs, milk, cheese, liver, meat, and poultry contain cholesterol).

Clinical Trials: Carefully controlled studies that are conducted to test the effectiveness and safety of new drugs, medical products, or techniques. All drugs in the U.S. undergo three phases of clinical trials before being approved for general use.

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Dawn Phenomenon: A rise in blood glucose levels that occurs in the early morning hours.

DCCT: The Diabetes Control and Complications Trial. A very large trial of people ages 13 to 39 years old, which showed that lower Hemoglobin A1C values resulted in a decreased risk for eye, kidney, and nerve problems. It ended in June 1993.

Diabetes Educator: A healthcare person who has the skill and knowledge to teach a person with diabetes how to manage the condition. Diabetes educators may be physicians, nurses, dietitians, mental health, or fitness clinicians. Some also may have the credential CDE (Certified Diabetes Educator).

Diabetic Ketoacidosis (also called ketoacidosis or DKA): A condition that results from a lack of sufficient insulin in the body, leading to high blood glucose levels and ketone formation. It is an extremely serious and life-threatening condition that may lead to coma and death. The symptoms of ketoacidosis are nausea, stomach pain, vomiting, chest pain, rapid shallow breathing, and difficulty staying awake.

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Endocrinologist: A physician who specializes in diseases of the endocrine system such as diabetes.

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Gastroparesis: A condition in which neuropathy affects the nerves controlling the digestive tract and causes difficulty processing or disposing of food. It can cause nausea, vomiting, bloating, or diarrhea.

Glucagon: A hormone that causes the blood sugar to rise. It is given by injection to people when they have become unconscious or have a seizure because of a low blood sugar.

Glucose: A simple form of sugar that is created when the body's digestive processes break down the food we eat. Glucose is the body's main source of energy.

Glycemic Index (GI): A system of ranking foods containing equal amounts of carbohydrate according to how much they raise blood glucose levels. For instance, the carbohydrate in a slice of 100% stone-ground whole wheat bread (a low glycemic index food) may have less impact on blood glucose than a slice of processed white bread (a high glycemic index food). The GI is an additional meal planning tool to help one understand how carbohydrate foods can differ in their effects on blood glucose.

Glycogen: Glucose that is stored in muscles and liver.

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HDL (high-density lipoprotein - also called "good" cholesterol): A type of blood cholesterol that sweeps excess cholesterol from the blood back to the liver where it is reprocessed or eliminated.

Hemoglobin A1C: A blood test that measures average blood glucose over the past 2 to 3 months and is the best way to measure overall glucose control. It should be measured 2 to 4 times a year and the goal is less than 7%.

Hormones: Chemical messengers made in one part of the body that transfer "information" through the bloodstream to cells in another part of the body. Insulin is a hormone.

Honeymoon Phase: The time right after the diagnosis of Type 1 diabetes when the pancreas is still making some insulin.

Hyperglycemia: High blood glucose levels. Blood glucose is generally considered "high" when it is 160 mg/dl or above your individual blood glucose target.

Hypertension: High blood pressure (blood flows through the blood vessels with a greater than normal force) which is defined as blood pressure equal to or greater than 130/80mm Hg for adults or greater than the 95th percentile for age in children and affects the majority of adults with diabetes. It increases one's risk of heart attack, stroke, and kidney problems.

Hypoglycemia: The term used for a low blood glucose.

Hypoglycemia Unawareness: A condition in which one no longer recognizes the symptoms of low blood glucose.

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Infusion Set: Plastic tubing used with an insulin pump.

Insulin: A hormone made in the pancreas that helps glucose pass into the cells where it is used to create energy for the body.

Insulin Pen: An insulin delivery method that looks like a writing pen.

Insulin Pump: A method of delivering basal/bolus insulin through an external device.

Insulin Resistance: A condition that makes it harder for the cells to properly use insulin. Teenagers, those who are overweight, and those with a family history of type 2 diabetes are at greater risk for insulin resistance.

Insulin Sensitivity Factor (also called the correction factor): The amount of blood glucose measured in mg/dl that is lowered by 1 unit of rapid-acting or regular insulin. The insulin sensitivity factor is used to calculate the amount of insulin you need to return blood glucose to within your target blood glucose range.

Insulin-to-Carbohydrate Ratio: A method of determining how much rapid-acting insulin is needed to cover the carbohydrate eaten at a meal or snack.

Islet Cell Antibody: The material in a person's blood that shows they have had an allergy against the cells in the pancreas (the islet cells) that make insulin.

Islet Cells: Cells that make insulin and are found within the pancreas; also called pancreatic beta cells.

Islet of Langerhans: Cells found in the pancreas.

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Ketones: The chemicals that appear in the urine when not enough insulin is present and fat is broken down.

Ketosis: The excessive formation of ketones in the blood.

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Lancet: A small needle used to get a drop of blood from your finger, arm, or other site. The blood is placed on a special strip, which is put into the meter. The meter "reads" the strip and gives a blood glucose reading.

Lifestyle Changes: Changes made to one's eating habits and physical activity in order to control blood glucose.

LDL (low-density lipoprotein or bad cholesterol): A type of blood cholesterol that can be deposited in the arteries, increasing the risk of heart attack or stroke.

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Microalbuminuria: The presence of small amounts of albumin, a protein, in the urine. Microalbuminuria is an early sign of kidney damage.

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Nephropathy: Serious kidney disease that can occur in people who have had diabetes for a long time, particularly if their diabetes has been poorly controlled.

Neuropathy: Damage to the nerves. It is a condition that can be very debilitating and painful. There are two main types of neuropathy, depending on which nerve cells are damaged. One type is called sensory neuropathy, which affects feelings in the legs or hands and is referred to as peripheral neuropathy. The other type is autonomic neuropathy, which affects nerves that control various organs, such as the stomach or urinary tract.

Nocturnal Hypoglycemia: Low blood glucose that occurs in the middle of the night.

Nutritive or Caloric Sweeteners: Sweeteners that contribute calories and can affect blood glucose levels.

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Pancreas: A small gland located below and just behind the stomach that makes a specific kind of hormone called insulin.

Proliferative Retinopathy: A more serious stage of diabetic retinopathy in which there is a greater loss of vision or even total blindness. During this stage, abnormal blood vessels grow over the surface of the retina.

Protein: One of the main nutrients from food along with carbohydrate and fat. The body uses protein to build and repair body tissue. Muscles, organs, bones, skin, and many of the hormones in the body are made from protein. As a secondary role, protein can also provide energy for the body if carbohydrate is not available. Food sources of protein include meat, poultry, fish, eggs, dairy products, and beans.

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Rapid-Acting Insulin: A type of insulin that begins to work to lower blood glucose within 10 to 30 minutes and works hardest 30 minutes to 3 hours after injection. There are three approved rapid-acting insulins: Humalog, Novolog, and Apidra.

Rebound Hyperglycemia (high blood glucose or the Somogyi Phenomenon): A condition in which, as a result of too low a level of glucose, the counter regulatory or stress hormones cause the liver to release too much glucose.

Retinopathy: Damage to the retina, the thin, light-sensitive inner lining in the back of the eye. This damage occurs to the small blood vessels in the retina which are easily harmed by high levels of glucose in the blood.

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Saturated Fat: A type of food fat that is solid at room temperature. Saturated fats raise blood cholesterol levels by interfering with the entry of cholesterol into cells causing cholesterol to remain in the bloodstream longer and to become a part of the plaque that builds up in the blood vessels.

Self-Monitoring: Managing one's diabetes by checking blood glucose, and being aware of food intake, physical activity and medication and how each of these elements work together in order to keep blood glucose in good control.

Sugar Alcohols or Polyols: Sweeteners that replace other sugars in foods causing slightly lower rises in blood glucose.

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Trans Fats: A type of fat formed from hydrogenation, a chemical process that changes a liquid oil into a solid fat. Trans fats are found in processed foods, such as snack foods, cookies, fast foods, and some stick or solid margarines. They can raise cholesterol levels and should be eaten in as small amounts as possible.

Triglycerides: A type of fat stored in fat cells as body fat and burned for energy. High levels of triglycerides are linked with an increased risk of heart and blood vessel disease.

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