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When does a child need a bone marrow transplant?
Bone marrow transplants (BMT) are often required for children with cancer, such as leukemia, lymphoma, aplastic anemia, tumors and other childhood cancers.
Why is Children's Mercy the best children's hospital for bone marrow transplant?
Children's Mercy Hospitals and Clinics in Kansas City is one of the leading children's hospitals in the Midwest. The bone marrow transplant center offers a highly skilled team of pediatric blood and marrow transplant specialists including Board certified pediatric hematologists, pediatric oncologists and surgeons. More than 60 patients have received bone marrow transplants at Children's Mercy in the last 3 years, with high survival rates that are comparable to the best published results.
What are common childhood cancer diagnoses requiring pediatric bone marrow transplant?
Pediatric Bone Marrow Transplantation services are for children with a variety of childhood cancers, including:
- Leukemia & lymphoma - acute lymphoblastic leukemia, acute myeloid leukemia, chronic myelocytic leukemia, Hodgkin's disease, non-Hodgkin's lymphoma
- Aplastic anemia - congenital hypoplastic anemia, failure of the bone marrow to produce blood cells, including red and white blood cells and platelets
- Solid childhood tumors - neuroblastoma, sarcomas, brain tumors
- Inherited disorders - immunodeficiencies, Fanconci pancytopenia syndrome, Wiskott-Aldrich syndrome, storage diseases and hemoglobinopathies
What pediatric bone marrow transplant services does Children's Mercy offer?
Children's Mercy is one of the few centers across the country that can provide mismatched bone marrow transplants for family members, as well as matched unrelated donor transplants via an international marrow search. Children's Mercy is also a leader in the use of mini-transplants using the donor's immune system to reduce the amount of chemotherapy needed for the transplant.
What are the different types of bone marrow transplants for children?
As one of the Midwest's leading pediatric bone marrow transplantation centers for children, we offer three types of BMT:
- Allogeneic Bone Marrow Transplant - when marrow from an unrelated adult or pediatric donor is used
- Synergeneic Bone Marrow Transplant - when marrow from an identical twin is used
- Autologous Bone Marrow Transplant - when the pediatric patient's own marrow is used
Additional pediatric bone marrow transplant services include:
- T-cell depleted transplants - T-cells sometimes -- when transplanted to a patient -- attack tissues and can cause graft versus host disease (GvHD). To minimize the chances that a patient will develop GvHD, specialists can modify the transplant before infusion by removing the T-cells.
- Mini-transplants - non-myeloablative transplants do not completely destroy the patient's diseased marrow. In this transplantation procedure, pediatric patients receive lower doses of chemotherapy drugs.
- High-dose chemotherapy with autologous stem cell rescue - high dose chemotherapy is used during a conditioning period to kill the tumor. Bone marrow function is then restored by infusing the pediatric patient's own previously-stored bone marrow cells.
For more information on pediatric bone marrow transplant, see Bone Marrow Transplant Consortium and Children's Mercy Care Cards.
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Diagnoses
Childhood Cancers
- Acute Lymphoblastic Leukemia (ALL)
- Acute Myelogenic Leukemia (AML)
- Brain tumors
- Ewing's Family of Sarcomas
- Liver Tumors
- Hodgkin's Disease
- Non-Hodgkin's Lymphoma
- Neuroblastomas
- Wilms' Tumor
- Osteosarcoma
- Retinoblastoma
- Rhabdomyosarcoma
- Other Childhood Cancers
Sickle Cell Disease
Hematologic Disorders
Physicians
- Dalal, Jignesh , MD
Assistant Professor of Pediatrics, UMKC School of Medicine - Gamis, Alan , MD
Section Chief, Oncology, Professor of Pediatrics, University of Missouri-Kansas City - Hetherington, Maxine , MD
Associate Professor of Pediatrics - Lewing, Karen , MD
Assistant Professor of Pediatrics - Manalang, Michelle , MD
Assistant Professor of Pediatrics, UMKC School of Medicine - Myers, Doug , MD
Assistant Professor of Pediatrics - Neville, Kathleen , MD
Assistant Professor of Pediatrics - Niece, J. Allyson , MD
Hematologist/Oncologist - Shore, Richard , MD
Assistant Professor of Pediatrics - Wicklund, Brian , MD
Director,Hemophilia/Coagulation/Thrombosis Program
Associate Professor of Pediatrics, UMKC School of Medicine - Woods, Gerald , MD
Division Chief, Hematology/Oncology
Section Chief, Hematology
Director, Sickle Cell Program
Professor of Pediatrics, UMKC School of Medicine
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